PDF(Pubmed)
Abstract：
The cornea, consisting of three cellular and two non-cellular layers, is the outermost part of the eyeball and frequently injured by external physical, chemical, and microbial insults. The epithelial-to-mesenchymal transition (EMT) plays a crucial role in the repair of corneal injuries. Zinc finger E-box binding homeobox 1 (ZEB1), an important transcription factor involved in EMT, is expressed in the corneal tissues. It regulates cell activities like migration, transformation, and proliferation, and thereby affects tissue inflammation, fibrosis, tumor metastasis, and necrosis by mediating various major signaling pathways, including transforming growth factor (TGF)-β. Dysfunction of ZEB1 would impair corneal tissue repair leading to epithelial healing delay, interstitial fibrosis, neovascularization, and squamous cell metaplasia. Understanding the mechanism underlying ZEB1 regulation of corneal injury repair will help us to formulate a therapeutic approach to enhance corneal injury repair.
摘要：
角膜,由三个细胞层和两个非细胞层组成，是眼球的最外面的部分，经常受到外部身体的伤害，化学,和微生物的侮辱。上皮间质转化（EMT）在角膜损伤的修复中起着至关重要的作用。锌指E盒结合homeobox1(ZEB1),参与EMT的重要转录因子，在角膜组织中表达。它调节细胞活动，如迁移，改造,和扩散，从而影响组织炎症，纤维化，肿瘤转移，和坏死通过介导各种主要信号通路，包括转化生长因子(TGF)-β。ZEB1的功能障碍会损害角膜组织修复，导致上皮愈合延迟，间质纤维化,新生血管形成,鳞状细胞化生.了解ZEB1调节角膜损伤修复的潜在机制将有助于我们制定增强角膜损伤修复的治疗方法。
