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Abstract：
BACKGROUND: Neurospecific Enolase (NSE), a multifunctional protein, is present in various tissues of the body and plays an important role in many disease processes, such as infection, inflammation, tumours, injury, and immunity. In recent years, the application of NSE in respiratory diseases has become increasingly widespread and a research hotspot.
OBJECTIVE: This study aims to explore the relationship between NSE and childhood pneumonia, providing assistance for the diagnosis and assessment of pneumonia.
METHODS: Using prospective research and case-control methods, We selected 129 children with pneumonia hospitalised in Weifang People\'s Hospital from September 2020 to April 2022 as the case group. Among them were 67 cases of Mycoplasma pneumoniae pneumonia (MP+), 62 cases of non-Mycoplasma pneumoniae pneumonia (MP -), and 21 cases of severe pneumonia. At the same time, 136 children who underwent outpatient health examinations were selected as the control group. The levels of NSE, ESR, CRP in cases group and NSE in control group were measured separately.
RESULTS: The NSE levels in the MP + group were 17.86 (14.29-22.54) ng/mL, while those in the MP- group were 17.89 (14.10-21.66) ng/mL, both of which were higher than the control group\'s NSE levels of 13.26(12.18,14.44) ng/mL (H = 46.92, P = 0.000). There was no statistically significant difference in NSE levels between the MP + and MP - groups (P > 0.05). The NSE level in the severe pneumonia group was 27.38 (13.95-34.06) ng/mL, higher than that in the mild pneumonia group, which was 17.68 (14.27-21.04) ng/mL, (P = 0.024). The AUC values for diagnosing pneumonia are NSE0.714, CRP0.539, and ESR0.535, with NSE having the highest diagnostic value.
CONCLUSIONS: Serum NSE can serve as an inflammatory indicator for paediatric pneumonia, which has important clinical guidance significance for the diagnosis, condition evaluation, and prognosis of paediatric pneumonia.
OBJECTIVE: This study aims to explore the relationship between NSE and childhood pneumonia, providing assistance for the diagnosis and assessment of pneumonia.
METHODS: Using prospective research and case-control methods, We selected 129 children with pneumonia hospitalised in Weifang People\'s Hospital from September 2020 to April 2022 as the case group. Among them were 67 cases of Mycoplasma pneumoniae pneumonia (MP+), 62 cases of non-Mycoplasma pneumoniae pneumonia (MP -), and 21 cases of severe pneumonia. At the same time, 136 children who underwent outpatient health examinations were selected as the control group. The levels of NSE, ESR, CRP in cases group and NSE in control group were measured separately.
RESULTS: The NSE levels in the MP + group were 17.86 (14.29-22.54) ng/mL, while those in the MP- group were 17.89 (14.10-21.66) ng/mL, both of which were higher than the control group\'s NSE levels of 13.26(12.18,14.44) ng/mL (H = 46.92, P = 0.000). There was no statistically significant difference in NSE levels between the MP + and MP - groups (P > 0.05). The NSE level in the severe pneumonia group was 27.38 (13.95-34.06) ng/mL, higher than that in the mild pneumonia group, which was 17.68 (14.27-21.04) ng/mL, (P = 0.024). The AUC values for diagnosing pneumonia are NSE0.714, CRP0.539, and ESR0.535, with NSE having the highest diagnostic value.
CONCLUSIONS: Serum NSE can serve as an inflammatory indicator for paediatric pneumonia, which has important clinical guidance significance for the diagnosis, condition evaluation, and prognosis of paediatric pneumonia.
摘要：
背景：神经特异性烯醇化酶（NSE），多功能蛋白质,存在于身体的各种组织中，在许多疾病过程中起着重要作用，如感染，炎症,肿瘤,损伤,和豁免权。近年来,NSE在呼吸系统疾病中的应用日益广泛,成为研究热点。
目的：本研究旨在探讨NSE与儿童肺炎的关系。为肺炎的诊断和评估提供帮助。
方法：使用前瞻性研究和病例对照方法，选取2020年9月至2022年4月在潍坊市人民医院住院的129例肺炎患儿作为病例组。其中肺炎支原体肺炎(MP+)67例,62例非肺炎支原体肺炎（MP-），和21例重症肺炎。同时,选取136例行门诊健康体检的患儿作为对照组。NSE的水平,ESR,分别测定病例组CRP和对照组NSE。
结果：MP+组的NSE水平为17.86（14.29-22.54）ng/mL，而MP-组为17.89（14.10-21.66）ng/mL，均高于对照组的NSE水平13.26(12.18,14.44)ng/mL(H=46.92,P=0.000)。MP+组和MP-组NSE水平差异无统计学意义(P>0.05)。重症肺炎组NSE水平为27.38(13.95-34.06)ng/mL,高于轻度肺炎组，17.68（14.27-21.04）ng/mL，（P=0.024）。诊断肺炎的AUC值为NSE0.714、CRP0.539和ESR0.535,其中NSE具有最高的诊断价值。
结论：血清NSE可作为小儿肺炎的炎性指标，对诊断具有重要的临床指导意义,条件评估,小儿肺炎的预后。
目的：本研究旨在探讨NSE与儿童肺炎的关系。为肺炎的诊断和评估提供帮助。
方法：使用前瞻性研究和病例对照方法，选取2020年9月至2022年4月在潍坊市人民医院住院的129例肺炎患儿作为病例组。其中肺炎支原体肺炎(MP+)67例,62例非肺炎支原体肺炎（MP-），和21例重症肺炎。同时,选取136例行门诊健康体检的患儿作为对照组。NSE的水平,ESR,分别测定病例组CRP和对照组NSE。
结果：MP+组的NSE水平为17.86（14.29-22.54）ng/mL，而MP-组为17.89（14.10-21.66）ng/mL，均高于对照组的NSE水平13.26(12.18,14.44)ng/mL(H=46.92,P=0.000)。MP+组和MP-组NSE水平差异无统计学意义(P>0.05)。重症肺炎组NSE水平为27.38(13.95-34.06)ng/mL,高于轻度肺炎组，17.68（14.27-21.04）ng/mL，（P=0.024）。诊断肺炎的AUC值为NSE0.714、CRP0.539和ESR0.535,其中NSE具有最高的诊断价值。
结论：血清NSE可作为小儿肺炎的炎性指标，对诊断具有重要的临床指导意义,条件评估,小儿肺炎的预后。
