Abstract：
The article by Ceppi and colleagues, Genotoxic Effects of Occupational Exposure to, Glass Fibres - A Human Biomonitoring Study, published in Mutation Research -Genetic Toxicology and Environmental Mutagenesis in 2023 was reviewed with great interest. The authors undertook a novel approach to conducting a biomonitoring study of genotoxicity markers among a population of glass fibre manufacturing workers in Slovakia. On the surface, the Ceppi et al. (2023) study provides an interesting application of genotoxicity markers among a human population of workers to explore potential markers of effect (DNA strand breaks) and potential risk of susceptibility (e.g., genetic damage, disease, death). However, limited data for exposure reconstruction, uncertain influences from smoking history, and lack of consideration of decades of human epidemiology research showing no increased risk of malignant or non-malignant respiratory disease and mortality among glass fibre manufacturing workers, reveals that the conclusions of the authors are overreaching and inconsistent with the existing science. The limitations of this study preclude the ability to draw causal inferences or conclusions about DNA strand breaks as a marker of exposure, effect, or susceptibility within this population of Slovakian glass fibre workers. Further longitudinal research is required (e.g., more robust temporal assessment of occupational exposures - fibres and other compounds - and smoking history) to support the study conclusions.
摘要：
塞皮和同事的文章，职业暴露的遗传毒性效应，玻璃纤维-人类生物监测研究，2023年发表在《突变研究-遗传毒理学和环境诱变》上的论文受到了极大的兴趣。作者采取了一种新颖的方法来对斯洛伐克的玻璃纤维制造工人群体中的遗传毒性标记进行生物监测研究。表面上,塞皮等人。（2023）研究提供了在工人人群中遗传毒性标记的有趣应用，以探索潜在的效应标记（DNA链断裂）和潜在的易感性风险（例如，遗传损伤,疾病,death).然而,曝光重建的数据有限，吸烟史的不确定影响，并且缺乏对数十年人类流行病学研究的考虑，这些研究表明玻璃纤维制造工人中恶性或非恶性呼吸系统疾病和死亡率的风险没有增加，揭示了作者的结论是过分的，与现有的科学不一致。这项研究的局限性排除了得出关于DNA链断裂作为暴露标记的因果关系或结论的能力，效果，或斯洛伐克玻璃纤维工人群体中的易感性。需要进一步的纵向研究(例如，对职业暴露-纤维和其他化合物-以及吸烟史进行更可靠的时间评估），以支持研究结论。
