Abstract：
Women have a 2-fold increased rate of stress-associated psychiatric disorders such as depression and anxiety, but the mechanisms that underlie this increased susceptibility remain incompletely understood. Historically, female subjects were excluded from preclinical studies and clinical trials. Additionally, chronic stress paradigms used to study psychiatric pathology in animal models were developed for use in males. However, recent changes in National Institutes of Health policy encourage inclusion of female subjects, and considerable work has been performed in recent years to understand biological sex differences that may underlie differences in susceptibility to chronic stress-associated psychiatric conditions. Here, we review the utility as well as current challenges of using the framework of the National Institute of Mental Health\'s Research Domain Criteria as a transdiagnostic approach to study sex differences in rodent models of chronic stress including recent progress in the study of sex differences in the neurobehavioral domains of negative valence, positive valence, cognition, social processes, and arousal.
摘要：
女性与压力相关的精神疾病如抑郁和焦虑的发生率增加了两倍，但是这种易感性增加的机制仍未完全了解。女性受试者在历史上被排除在临床前研究和临床试验之外。此外,在动物模型中用于研究精神病理学的慢性应激范式是为男性开发的。然而,NIH政策的最新变化鼓励女性受试者的纳入，近年来，已经进行了大量的工作来了解生物学上的性别差异，这些差异可能是与慢性压力相关的精神疾病易感性差异的基础。我们在这里回顾了使用NIH研究领域标准的框架作为一种跨诊断方法来研究慢性应激啮齿动物模型中的性别差异的效用以及当前的挑战，包括神经行为领域性别差异研究的最新进展。正价，认知，社会进程,唤醒,和社会进程。
