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Abstract：
Heart failure (HF) refers to a group of clinical syndromes in which various heart diseases lead to the inability of cardiac output to meet the metabolic needs of the body\'s tissues. Cardiac metabolism requires enormous amounts of energy; thus, impaired myocardial energy metabolism is considered a key factor in the occurrence and development of HF. Mitochondria serve as the primary energy source for cardiomyocytes, and their regular functionality underpins healthy cardiac function. The mitochondrial quality control system is a crucial mechanism for regulating the functionality of cardiomyocytes, and any abnormality in this system can potentially impact the morphology and structure of mitochondria, as well as the energy metabolism of cardiomyocytes. Phosphoglycerate mutase 5 (PGAM5), a multifunctional protein, plays a key role in the regulation of mitochondrial quality control through multiple pathways. Therefore, abnormal PGAM5 function is closely related to mitochondrial damage. This article reviews the mechanism of PGAM5\'s involvement in the regulation of the mitochondrial quality control system in the occurrence and development of HF, thereby providing a theoretical basis for future in-depth research.
摘要：
心力衰竭是指一组临床综合征，其中各种心脏病导致心输出量无法满足人体组织的代谢需求。心脏代谢需要大量的能量；因此，心肌能量代谢受损被认为是心力衰竭发生发展的关键因素。线粒体是心肌细胞的主要能量来源,它们的常规功能支撑着健康的心脏功能。线粒体质量控制系统是调节心肌细胞功能的重要机制。这个系统中的任何异常都可能影响线粒体的形态和结构，以及心肌细胞的能量代谢。PGAM5，一种多功能蛋白质，通过多种途径在线粒体质量控制中发挥关键作用。因此,PGAM5功能异常与线粒体损伤密切相关。本文就PGAM5参与线粒体质量控制系统在心力衰竭发生发展中的作用机制进行综述,从而为今后的深入研究提供理论基础。
