Abstract：
The healing of a wound under tension (hereafter, \"tension wound\") often coincides with the development of hypertrophic scars in clinical settings. Currently, compress bandages offer a potential alternative for the healing of tension wounds; however, their application in surgery is limited due to their prefabricated patch form. To overcome this, a tension-shielding hydrogel system was designed using photocurable catechol-grafted hyaluronic acid and tannic-acid silver nanoparticles (hereafter, \"HTA system\"). The hydrogel exhibited tension-shielding capacity, reducing wound tension via shape-fixation and ultimately reducing scar formation. The HTA hydrogel exhibited superior photothermal antibacterial efficacy, self-healing properties, and effective dissipation of energy, thereby promoting tissue regeneration. The hydrogel significantly inhibited the mechanotransduction pathway, thus preventing Engrailed-1 activation and reducing the fibrotic response. The HTA hydrogel system, therefore, provides a treatment strategy for tension wounds, burn wounds and other wounds that are prone to form hypertrophic scars via creating a tension-free local environment. STATEMENT OF SIGNIFICANCE: In our study, we presented a wound-dressing hydrogel system (HTA) that exhibit shape-fixing capacity in tension wound model. Here, we designed and modified a tension regulator, applied it to mice, and furthermore, established a tension wound model in mice with adjustable tension. Outcomes showed that the HTA hydrogel system can effectively form a shape-fixed environment on tension wounds and dynamic wounds, thus promoting scarless healing. Additionally, HTA performs injectability, rapid crosslinking, biocompatibility, wet adhesion, hemostasis and photothermal antibacterial properties. We believe this research has various potential clinical applications, including scarless-healing in tension wounds, treatment of acute bleeding, treatment of infected wounds, and even internal organ repair.
摘要：
在张力下伤口的愈合（以下，“张力伤口”）通常与临床环境中肥厚性疤痕的发展相吻合。目前,压缩绷带为张力伤口的愈合提供了一个潜在的替代方案;然而，由于它们的预制补片形式，它们在手术中的应用受到限制。为了克服这一点，使用可光固化的邻苯二酚接枝的透明质酸和单宁酸银纳米颗粒（以下，\"HTA系统\")。水凝胶表现出张力屏蔽能力，通过形状固定减少伤口张力并最终减少疤痕形成。HTA水凝胶表现出优越的光热抗菌功效，自我修复特性，和有效的能量耗散，从而促进组织再生。水凝胶显著抑制了机械传导途径，从而防止Engraied-1激活和减少纤维化反应。HTA水凝胶系统，因此,为紧张的伤口提供了治疗策略，通过创造无张力的局部环境，烧伤伤口和其他容易形成肥厚性疤痕的伤口。重要声明：在我们的研究中，我们提出了一种伤口敷料水凝胶系统（HTA），在张力伤口模型中表现出形状固定能力。这里,我们设计并改装了一个张力调节器,把它应用到老鼠身上，而且,建立了张力可调节的小鼠张力伤口模型。结果表明，HTA水凝胶系统可以有效地在张力伤口和动态伤口上形成形状固定的环境，从而促进无疤痕愈合。此外,HTA执行可注射性，快速交联,生物相容性，湿附着力,止血和光热抗菌性能。我们相信这项研究具有各种潜在的临床应用，包括紧张伤口的无疤痕愈合，急性出血的治疗，感染伤口的治疗，甚至是内脏器官修复。
