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Abstract：
BACKGROUND: Risk factors associated with negative outcomes in dogs with protein-losing enteropathy (PLE) are well documented. However, mortality before hospital discharge and associated risk factors are not well described.
OBJECTIVE: Report the percentage of dogs with PLE that do not survive to hospital discharge and identify associated risk factors.
METHODS: One-hundred and seven dogs presented to a referral hospital and diagnosed with PLE caused by inflammatory enteritis, intestinal lymphangiectasia or both.
METHODS: Retrospective cross-sectional study assessing hospital records. Data on in-hospital mortality and cause were assessed, and presenting signs, treatments prescribed, neutrophil count, lymphocyte count, serum albumin, globulin, and C-reactive protein (CRP) concentrations, and histopathologic findings were compared between survivors and non-survivors.
RESULTS: In-hospital mortality was 21.5% with the most common causes including financial limitations, failure to improve and aspiration pneumonia. Factors associated with mortality during hospitalization included longer duration of hospitalization (P = .04), longer duration of clinical signs (P = .02) and an increase in serum CRP concentration after 1-3 days of in-hospital treatment (P = .02). Higher mortality was identified in Pugs (odds ratio [OR], 4.93; 95% confidence interval [CI], 1.41-17.2; P = .01) and was a result of presumptive aspiration pneumonia in 5/6 of these dogs.
CONCLUSIONS: Protein-losing enteropathy in dogs has substantial mortality during hospitalization. Monitoring for improvement in CRP concentration after treatment during hospitalization may help predict survival to discharge. Pugs have increased in-hospital mortality because of aspiration pneumonia; measures to prevent, recognize, and promptly treat this complication may improve outcomes in this breed.
OBJECTIVE: Report the percentage of dogs with PLE that do not survive to hospital discharge and identify associated risk factors.
METHODS: One-hundred and seven dogs presented to a referral hospital and diagnosed with PLE caused by inflammatory enteritis, intestinal lymphangiectasia or both.
METHODS: Retrospective cross-sectional study assessing hospital records. Data on in-hospital mortality and cause were assessed, and presenting signs, treatments prescribed, neutrophil count, lymphocyte count, serum albumin, globulin, and C-reactive protein (CRP) concentrations, and histopathologic findings were compared between survivors and non-survivors.
RESULTS: In-hospital mortality was 21.5% with the most common causes including financial limitations, failure to improve and aspiration pneumonia. Factors associated with mortality during hospitalization included longer duration of hospitalization (P = .04), longer duration of clinical signs (P = .02) and an increase in serum CRP concentration after 1-3 days of in-hospital treatment (P = .02). Higher mortality was identified in Pugs (odds ratio [OR], 4.93; 95% confidence interval [CI], 1.41-17.2; P = .01) and was a result of presumptive aspiration pneumonia in 5/6 of these dogs.
CONCLUSIONS: Protein-losing enteropathy in dogs has substantial mortality during hospitalization. Monitoring for improvement in CRP concentration after treatment during hospitalization may help predict survival to discharge. Pugs have increased in-hospital mortality because of aspiration pneumonia; measures to prevent, recognize, and promptly treat this complication may improve outcomes in this breed.
摘要：
背景：在患有蛋白质丢失性肠病（PLE）的狗中，与阴性结果相关的危险因素有很好的记录。然而,出院前的死亡率和相关的危险因素没有得到很好的描述.
目的：报告出院后无法存活的PLE犬的百分比，并确定相关的危险因素。
方法：一百零七只狗被送到转诊医院，并被诊断为炎症性肠炎引起的PLE，肠淋巴管扩张症或两者兼有。
方法：回顾性横断面研究评估医院记录。评估了住院死亡率和原因的数据，并呈现迹象，规定的治疗方法，中性粒细胞计数,淋巴细胞计数,血清白蛋白,球蛋白,和C反应蛋白（CRP）浓度，并比较了幸存者和非幸存者的组织病理学结果.
结果：住院死亡率为21.5%，最常见的原因包括经济限制，未能改善和吸入性肺炎。住院期间与死亡率相关的因素包括住院时间较长（P=0.04），临床体征持续时间较长（P=.02），住院治疗1-3天后血清CRP浓度升高（P=.02）。在哈巴狗中发现了更高的死亡率(比值比[OR]，4.93；95%置信区间[CI]，1.41-17.2;P=.01），是这些狗中5/6的推定吸入性肺炎的结果。
结论：犬的蛋白质丢失性肠病在住院期间有相当大的死亡率。监测住院期间治疗后CRP浓度的改善可能有助于预测出院后的生存率。由于吸入性肺炎，哈巴狗的住院死亡率增加；预防措施，认识到，及时治疗这种并发症可能会改善该品种的预后。
目的：报告出院后无法存活的PLE犬的百分比，并确定相关的危险因素。
方法：一百零七只狗被送到转诊医院，并被诊断为炎症性肠炎引起的PLE，肠淋巴管扩张症或两者兼有。
方法：回顾性横断面研究评估医院记录。评估了住院死亡率和原因的数据，并呈现迹象，规定的治疗方法，中性粒细胞计数,淋巴细胞计数,血清白蛋白,球蛋白,和C反应蛋白（CRP）浓度，并比较了幸存者和非幸存者的组织病理学结果.
结果：住院死亡率为21.5%，最常见的原因包括经济限制，未能改善和吸入性肺炎。住院期间与死亡率相关的因素包括住院时间较长（P=0.04），临床体征持续时间较长（P=.02），住院治疗1-3天后血清CRP浓度升高（P=.02）。在哈巴狗中发现了更高的死亡率(比值比[OR]，4.93；95%置信区间[CI]，1.41-17.2;P=.01），是这些狗中5/6的推定吸入性肺炎的结果。
结论：犬的蛋白质丢失性肠病在住院期间有相当大的死亡率。监测住院期间治疗后CRP浓度的改善可能有助于预测出院后的生存率。由于吸入性肺炎，哈巴狗的住院死亡率增加；预防措施，认识到，及时治疗这种并发症可能会改善该品种的预后。
