OBJECTIVE: Report the percentage of dogs with PLE that do not survive to hospital discharge and identify associated risk factors.
METHODS: One-hundred and seven dogs presented to a referral hospital and diagnosed with PLE caused by inflammatory enteritis, intestinal lymphangiectasia or both.
METHODS: Retrospective cross-sectional study assessing hospital records. Data on in-hospital mortality and cause were assessed, and presenting signs, treatments prescribed, neutrophil count, lymphocyte count, serum albumin, globulin, and C-reactive protein (CRP) concentrations, and histopathologic findings were compared between survivors and non-survivors.
RESULTS: In-hospital mortality was 21.5% with the most common causes including financial limitations, failure to improve and aspiration pneumonia. Factors associated with mortality during hospitalization included longer duration of hospitalization (P = .04), longer duration of clinical signs (P = .02) and an increase in serum CRP concentration after 1-3 days of in-hospital treatment (P = .02). Higher mortality was identified in Pugs (odds ratio [OR], 4.93; 95% confidence interval [CI], 1.41-17.2; P = .01) and was a result of presumptive aspiration pneumonia in 5/6 of these dogs.
CONCLUSIONS: Protein-losing enteropathy in dogs has substantial mortality during hospitalization. Monitoring for improvement in CRP concentration after treatment during hospitalization may help predict survival to discharge. Pugs have increased in-hospital mortality because of aspiration pneumonia; measures to prevent, recognize, and promptly treat this complication may improve outcomes in this breed.
目的:报告出院后无法存活的PLE犬的百分比,并确定相关的危险因素。
方法:一百零七只狗被送到转诊医院,并被诊断为炎症性肠炎引起的PLE,肠淋巴管扩张症或两者兼有。
方法:回顾性横断面研究评估医院记录。评估了住院死亡率和原因的数据,并呈现迹象,规定的治疗方法,中性粒细胞计数,淋巴细胞计数,血清白蛋白,球蛋白,和C反应蛋白(CRP)浓度,并比较了幸存者和非幸存者的组织病理学结果.
结果:住院死亡率为21.5%,最常见的原因包括经济限制,未能改善和吸入性肺炎。住院期间与死亡率相关的因素包括住院时间较长(P=0.04),临床体征持续时间较长(P=.02),住院治疗1-3天后血清CRP浓度升高(P=.02)。在哈巴狗中发现了更高的死亡率(比值比[OR],4.93;95%置信区间[CI],1.41-17.2;P=.01),是这些狗中5/6的推定吸入性肺炎的结果。
结论:犬的蛋白质丢失性肠病在住院期间有相当大的死亡率。监测住院期间治疗后CRP浓度的改善可能有助于预测出院后的生存率。由于吸入性肺炎,哈巴狗的住院死亡率增加;预防措施,认识到,及时治疗这种并发症可能会改善该品种的预后。