Abstract：
The skin is the largest organ of the human body and is widely considered to be the first-line defense of the body, providing essential protection against mechanical, physical, and chemical damage. Keratinocytes are the primary cells of the outer layer of the epidermis, which acts as a mechanical and permeability barrier. The epidermis is a permanently renewed tissue where undifferentiated keratinocytes located at the basal layer proliferate and migrate to the overlying layers. Here we report that some components of keratinocytes affect the formation and differentiation of the stratum corneum, which is the most specialized layer of the epidermis.
摘要：
皮肤是人体最大的器官，被广泛认为是人体的一线防御，提供必要的机械保护，物理，和化学损伤。角质形成细胞是表皮外层的原代细胞，起到机械和渗透屏障的作用。表皮是永久更新的组织,其中位于基底层的未分化角质形成细胞增殖并迁移到上覆层。在这里，我们报道了角质形成细胞的一些成分影响角质层的形成和分化，这是表皮中最特殊的一层。
