PDF(Pubmed)
Abstract：
UNASSIGNED: Ultrasound-guided core needle biopsy combined with immunohistochemistry and molecular testing could improve the diagnostic accuracy of bone metastases from follicular thyroid carcinoma, help to predict distant metastasis and prognosis.
UNASSIGNED: Metastatic thyroid follicular carcinoma presenting initially with bone lesion is uncommon, its prime symptom is gradual onset, localized pain. Patient with bone metastasis who were diagnosed before thyroidectomy had a higher rate of mortality, clinician should be cautious in eliciting the clinical history and this insidious symptom in middle age group, carry out further examination. We are presenting two case reports of a follicular thyroid carcinoma with bone metastasis, ultrasound-guided core needle biopsy combined with immunohistochemistry (IHC) were carried out by our clinical team to determine the source and nature of the tumor, relevant literature was reviewed, molecular testing was discussed, we believe core needle biopsy combined with IHC and molecular testing improve the diagnostic accuracy of bone metastases from follicular thyroid carcinoma.
UNASSIGNED: Metastatic thyroid follicular carcinoma presenting initially with bone lesion is uncommon, its prime symptom is gradual onset, localized pain. Patient with bone metastasis who were diagnosed before thyroidectomy had a higher rate of mortality, clinician should be cautious in eliciting the clinical history and this insidious symptom in middle age group, carry out further examination. We are presenting two case reports of a follicular thyroid carcinoma with bone metastasis, ultrasound-guided core needle biopsy combined with immunohistochemistry (IHC) were carried out by our clinical team to determine the source and nature of the tumor, relevant literature was reviewed, molecular testing was discussed, we believe core needle biopsy combined with IHC and molecular testing improve the diagnostic accuracy of bone metastases from follicular thyroid carcinoma.
摘要：
■超声引导下穿刺活检结合免疫组织化学和分子检测可以提高滤泡性甲状腺癌骨转移的诊断准确性，有助于预测远处转移和预后。
■转移性甲状腺滤泡癌最初伴有骨病变并不常见，它的主要症状是逐渐发作，局部疼痛。在甲状腺切除术前诊断为骨转移的患者死亡率较高，临床医生应谨慎寻找中年人群的临床病史和这种隐匿的症状，进行进一步检查。我们提供两个滤泡性甲状腺癌骨转移的病例报告，我们的临床团队进行了超声引导下穿刺活检结合免疫组织化学（IHC）以确定肿瘤的来源和性质，回顾了相关文献，讨论了分子测试，我们认为粗针活检结合IHC和分子检测可提高甲状腺滤泡癌骨转移的诊断准确性.
■转移性甲状腺滤泡癌最初伴有骨病变并不常见，它的主要症状是逐渐发作，局部疼痛。在甲状腺切除术前诊断为骨转移的患者死亡率较高，临床医生应谨慎寻找中年人群的临床病史和这种隐匿的症状，进行进一步检查。我们提供两个滤泡性甲状腺癌骨转移的病例报告，我们的临床团队进行了超声引导下穿刺活检结合免疫组织化学（IHC）以确定肿瘤的来源和性质，回顾了相关文献，讨论了分子测试，我们认为粗针活检结合IHC和分子检测可提高甲状腺滤泡癌骨转移的诊断准确性.
