PDF(Pubmed)
Abstract：
BACKGROUND: Appendectomy is an acute abdominal surgery that is often accompanied by severe abdominal inflammation. Oral probiotics are one of the postoperative treatments for rapid rehabilitation. However, there is a lack of prospective studies on this topic after appendectomy.
OBJECTIVE: To investigate whether the postoperative probiotics can modulate the inflammatory response and restore intestinal function in patients following appendectomy.
METHODS: This was a prospective, randomized trial. A total of 60 emergency patients were randomly divided into a control group (n = 30) and a probiotic group (n = 30). Patients in the control group started to drink some water the first day after surgery, and those in the probiotic group were given water supplemented with Bacillus licheniformis capsules for 5 consecutive days postsurgery. The indices of inflammation and postoperative conditions were recorded, and the data were analyzed with RStudio 4.3.2 software.
RESULTS: A total of 60 participants were included. Compared with those in the control group, the C-reactive protein (CRP), interleukin 6 and procalcitonin (PCT) levels were significantly lower in the probiotic group at 2 d after surgery (P = 2.224e-05, P = 0.037, and P = 0.002, respectively, all P < 0.05). This trend persisted at day 5 post-surgery, with CRP and PCT levels remaining significantly lower in the probiotic group (P = 0.001 and P = 0.043, both P < 0.05). Furthermore, probiotics resulted in a shorter time to first flatus and a greater percentage of gram-negative bacilli in the feces (P = 0.035, P = 0.028, both P < 0.05).
CONCLUSIONS: Postoperative oral administration of probiotics may modulate the gut microbiota, benefit the recovery of the early inflammatory response, and subsequently enhance recovery after appendectomy.
OBJECTIVE: To investigate whether the postoperative probiotics can modulate the inflammatory response and restore intestinal function in patients following appendectomy.
METHODS: This was a prospective, randomized trial. A total of 60 emergency patients were randomly divided into a control group (n = 30) and a probiotic group (n = 30). Patients in the control group started to drink some water the first day after surgery, and those in the probiotic group were given water supplemented with Bacillus licheniformis capsules for 5 consecutive days postsurgery. The indices of inflammation and postoperative conditions were recorded, and the data were analyzed with RStudio 4.3.2 software.
RESULTS: A total of 60 participants were included. Compared with those in the control group, the C-reactive protein (CRP), interleukin 6 and procalcitonin (PCT) levels were significantly lower in the probiotic group at 2 d after surgery (P = 2.224e-05, P = 0.037, and P = 0.002, respectively, all P < 0.05). This trend persisted at day 5 post-surgery, with CRP and PCT levels remaining significantly lower in the probiotic group (P = 0.001 and P = 0.043, both P < 0.05). Furthermore, probiotics resulted in a shorter time to first flatus and a greater percentage of gram-negative bacilli in the feces (P = 0.035, P = 0.028, both P < 0.05).
CONCLUSIONS: Postoperative oral administration of probiotics may modulate the gut microbiota, benefit the recovery of the early inflammatory response, and subsequently enhance recovery after appendectomy.
摘要：
背景：阑尾切除术是一种急性腹部手术，通常伴有严重的腹部炎症。口服益生菌是术后快速康复的治疗方法之一。然而,阑尾切除术后缺乏关于这一主题的前瞻性研究.
目的：探讨术后益生菌是否能调节阑尾切除术后患者的炎症反应和恢复肠道功能。
方法：这是一个前瞻性的，随机试验。将60例急诊患者随机分为对照组(n=30)和益生菌组(n=30)。对照组患者在手术后第一天开始喝水，益生菌组术后连续5天给予补充地衣芽孢杆菌胶囊的水。记录炎症指标及术后情况,数据采用RStudio4.3.2软件进行分析。
结果：共纳入60名参与者。与对照组相比，C反应蛋白（CRP），术后2d,益生菌组白细胞介素6和降钙素原(PCT)水平明显降低(P=2.224e-05,P=0.037,P=0.002,所有P<0.05)。这种趋势在手术后第5天持续存在，益生菌组的CRP和PCT水平保持显着降低（P=0.001和P=0.043，均P<0.05）。此外，益生菌导致首次排气时间更短，粪便中革兰氏阴性杆菌的百分比更高（P=0.035，P=0.028，均P<0.05）。
结论：术后口服益生菌可能会调节肠道菌群，有利于早期炎症反应的恢复，随后增强阑尾切除术后的恢复。
目的：探讨术后益生菌是否能调节阑尾切除术后患者的炎症反应和恢复肠道功能。
方法：这是一个前瞻性的，随机试验。将60例急诊患者随机分为对照组(n=30)和益生菌组(n=30)。对照组患者在手术后第一天开始喝水，益生菌组术后连续5天给予补充地衣芽孢杆菌胶囊的水。记录炎症指标及术后情况,数据采用RStudio4.3.2软件进行分析。
结果：共纳入60名参与者。与对照组相比，C反应蛋白（CRP），术后2d,益生菌组白细胞介素6和降钙素原(PCT)水平明显降低(P=2.224e-05,P=0.037,P=0.002,所有P<0.05)。这种趋势在手术后第5天持续存在，益生菌组的CRP和PCT水平保持显着降低（P=0.001和P=0.043，均P<0.05）。此外，益生菌导致首次排气时间更短，粪便中革兰氏阴性杆菌的百分比更高（P=0.035，P=0.028，均P<0.05）。
结论：术后口服益生菌可能会调节肠道菌群，有利于早期炎症反应的恢复，随后增强阑尾切除术后的恢复。
