%0 Journal Article
%T Effects of oral probiotics on inflammation and intestinal function in adult patients after appendectomy: Randomized controlled trial.
%A Lan K
%A Zeng KR
%A Zhong FR
%A Tu SJ
%A Luo JL
%A Shu SL
%A Peng XF
%A Yang H
%A Lu K
%J World J Gastrointest Surg
%V 16
%N 5
%D 2024 May 27
%M 38817278
暂无%R 10.4240/wjgs.v16.i5.1371
%X <B>BACKGROUND: </B>Appendectomy is an acute abdominal surgery that is often accompanied by severe abdominal inflammation. Oral probiotics are one of the postoperative treatments for rapid rehabilitation. However, there is a lack of prospective studies on this topic after appendectomy.<BR><B>OBJECTIVE: </B>To investigate whether the postoperative probiotics can modulate the inflammatory response and restore intestinal function in patients following appendectomy.<BR><B>METHODS: </B>This was a prospective, randomized trial. A total of 60 emergency patients were randomly divided into a control group (n = 30) and a probiotic group (n = 30). Patients in the control group started to drink some water the first day after surgery, and those in the probiotic group were given water supplemented with Bacillus licheniformis capsules for 5 consecutive days postsurgery. The indices of inflammation and postoperative conditions were recorded, and the data were analyzed with RStudio 4.3.2 software.<BR><B>RESULTS: </B>A total of 60 participants were included. Compared with those in the control group, the C-reactive protein (CRP), interleukin 6 and procalcitonin (PCT) levels were significantly lower in the probiotic group at 2 d after surgery (P = 2.224e-05, P = 0.037, and P = 0.002, respectively, all P < 0.05). This trend persisted at day 5 post-surgery, with CRP and PCT levels remaining significantly lower in the probiotic group (P = 0.001 and P = 0.043, both P < 0.05). Furthermore, probiotics resulted in a shorter time to first flatus and a greater percentage of gram-negative bacilli in the feces (P = 0.035, P = 0.028, both P < 0.05).<BR><B>CONCLUSIONS: </B>Postoperative oral administration of probiotics may modulate the gut microbiota, benefit the recovery of the early inflammatory response, and subsequently enhance recovery after appendectomy.