PDF(Pubmed)
Abstract：
BACKGROUND: The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its subsequent Omicron variant has raised concerns for chronic obstructive pulmonary disease (COPD) patients due to the potential risk of disruptions to healthcare services and unknown comorbidities between COPD and Omicron.
METHODS: In this study, we conducted a follow-up investigation of 315 COPD patients during the Omicron outbreak at Shanxi Bethune Hospital to understand the impact of the pandemic on this vulnerable population. Among all patients, 228 were infected with Omicron, of which 82 needed hospitalizations.
RESULTS: We found that COPD patients with high blood eosinophil (EOS) counts exhibited lower susceptibility to Omicron infection and were more likely to have milder symptoms that did not require hospitalization. Conversely, patients with low EOS counts showed higher rates of infection and hospitalization. Moreover, EOS count was positively correlated with T lymphocyte counts in hospitalized patients after Omicron infection, suggesting potential associations between EOS and specific immune responses in COPD patients during viral infections. Correlation analysis revealed a positive correlation between EOS count and lymphocyte and T-cells, and a negative correlation between EOS count and age, neutrophil, and C-reactive protein.
CONCLUSIONS: Overall, our study contributes to the knowledge of COPD management during the COVID-19 Omicron outbreak and emphasizes the importance of considering individual immune profiles to improve care for COPD patients in the face of the ongoing global health crisis.
METHODS: In this study, we conducted a follow-up investigation of 315 COPD patients during the Omicron outbreak at Shanxi Bethune Hospital to understand the impact of the pandemic on this vulnerable population. Among all patients, 228 were infected with Omicron, of which 82 needed hospitalizations.
RESULTS: We found that COPD patients with high blood eosinophil (EOS) counts exhibited lower susceptibility to Omicron infection and were more likely to have milder symptoms that did not require hospitalization. Conversely, patients with low EOS counts showed higher rates of infection and hospitalization. Moreover, EOS count was positively correlated with T lymphocyte counts in hospitalized patients after Omicron infection, suggesting potential associations between EOS and specific immune responses in COPD patients during viral infections. Correlation analysis revealed a positive correlation between EOS count and lymphocyte and T-cells, and a negative correlation between EOS count and age, neutrophil, and C-reactive protein.
CONCLUSIONS: Overall, our study contributes to the knowledge of COPD management during the COVID-19 Omicron outbreak and emphasizes the importance of considering individual immune profiles to improve care for COPD patients in the face of the ongoing global health crisis.
摘要：
背景：严重急性呼吸综合征冠状病毒2（SARS-CoV-2）及其随后的Omicron变体的出现引起了对慢性阻塞性肺疾病（COPD）患者的关注，因为COPD和Omicron之间存在潜在的医疗保健服务中断风险和未知的合并症。
方法：在本研究中，我们对山西白求恩医院Omicron暴发期间315例COPD患者进行了随访调查,以了解大流行对该易感人群的影响.在所有患者中，228人感染了Omicron,其中82人需要住院治疗。
结果：我们发现，血液嗜酸性粒细胞（EOS）计数高的COPD患者对Omicron感染的易感性较低，并且更有可能出现不需要住院治疗的轻度症状。相反，EOS计数低的患者表现出更高的感染率和住院率.此外，Omicron感染后住院患者的EOS计数与T淋巴细胞计数呈正相关,提示EOS与COPD患者在病毒感染期间的特异性免疫反应之间的潜在关联。相关分析显示EOS计数与淋巴细胞和T细胞呈正相关,EOS计数和年龄之间呈负相关，中性粒细胞,和C反应蛋白.
结论：总体而言，我们的研究有助于在COVID-19Omicron爆发期间了解COPD的管理,并强调在当前的全球健康危机面前考虑个体免疫状况以改善COPD患者的护理的重要性.
方法：在本研究中，我们对山西白求恩医院Omicron暴发期间315例COPD患者进行了随访调查,以了解大流行对该易感人群的影响.在所有患者中，228人感染了Omicron,其中82人需要住院治疗。
结果：我们发现，血液嗜酸性粒细胞（EOS）计数高的COPD患者对Omicron感染的易感性较低，并且更有可能出现不需要住院治疗的轻度症状。相反，EOS计数低的患者表现出更高的感染率和住院率.此外，Omicron感染后住院患者的EOS计数与T淋巴细胞计数呈正相关,提示EOS与COPD患者在病毒感染期间的特异性免疫反应之间的潜在关联。相关分析显示EOS计数与淋巴细胞和T细胞呈正相关,EOS计数和年龄之间呈负相关，中性粒细胞,和C反应蛋白.
结论：总体而言，我们的研究有助于在COVID-19Omicron爆发期间了解COPD的管理,并强调在当前的全球健康危机面前考虑个体免疫状况以改善COPD患者的护理的重要性.
