PDF(Pubmed)
Abstract：
Clinical risk factors associated obesity and smoking, as well as their combined effect, are not fully understood. This study aims to determine sex differences in risk factors in a population of acute ischemic stroke (AIS) patients who are obese and with a history of previous or current smoking.
METHODS: A retrospective analysis of risk factors in male and female AIS patients with baseline data of obesity and current or previous history of smoking, smoking, and obesity alone was determined. The primary predictor and outcome are risk factors associated with male and female AIS patients. Baseline risk factors were analyzed using a multivariate regression analysis to determine specific risk factors linked with the combined effect of obesity and current or previous history of smoking\'\'.
RESULTS: Male obese AIS patients who are current or previous smokers were more likely to be older patients(OR = 1.024, 95% CI, 1.022-1.047, P = 0.033) that present with coronary artery disease (OR = 1.806, 95% CI, 1.028-3.174, P = 0.040), a history of alcohol use (OR = 2.873, 95% CI, 1.349-6.166, P = 0.006), elevated serum creatinine (OR = 4.724, 95% CI, 2.171-10.281, P < 0.001) and systolic blood pressure (OR = 1.029, 95% CI, 1.011-1.047, P < 0.002). Females were more associated with depression (OR = 0.432, 95% CI, 0.244-0.764, P = 0.004), previous TIA (OR = 0.319, 95% CI, 0.142-0.714, P < 0.005), and higher levels of HDL (OR = 0.938, 95% CI, 0.915-0.962, P < 0.001).
CONCLUSIONS: Our results reveal sex differences in risk factors in obese AIS patients with a current or past history of smoking. This finding emphasizes the need to develop management strategies to improve the care of obese AIS patients who are either current or former smokers.
METHODS: A retrospective analysis of risk factors in male and female AIS patients with baseline data of obesity and current or previous history of smoking, smoking, and obesity alone was determined. The primary predictor and outcome are risk factors associated with male and female AIS patients. Baseline risk factors were analyzed using a multivariate regression analysis to determine specific risk factors linked with the combined effect of obesity and current or previous history of smoking\'\'.
RESULTS: Male obese AIS patients who are current or previous smokers were more likely to be older patients(OR = 1.024, 95% CI, 1.022-1.047, P = 0.033) that present with coronary artery disease (OR = 1.806, 95% CI, 1.028-3.174, P = 0.040), a history of alcohol use (OR = 2.873, 95% CI, 1.349-6.166, P = 0.006), elevated serum creatinine (OR = 4.724, 95% CI, 2.171-10.281, P < 0.001) and systolic blood pressure (OR = 1.029, 95% CI, 1.011-1.047, P < 0.002). Females were more associated with depression (OR = 0.432, 95% CI, 0.244-0.764, P = 0.004), previous TIA (OR = 0.319, 95% CI, 0.142-0.714, P < 0.005), and higher levels of HDL (OR = 0.938, 95% CI, 0.915-0.962, P < 0.001).
CONCLUSIONS: Our results reveal sex differences in risk factors in obese AIS patients with a current or past history of smoking. This finding emphasizes the need to develop management strategies to improve the care of obese AIS patients who are either current or former smokers.
摘要：
与肥胖和吸烟相关的临床危险因素，以及它们的综合作用，没有完全理解。这项研究旨在确定肥胖且有既往或当前吸烟史的急性缺血性中风（AIS）患者人群中危险因素的性别差异。
方法：回顾性分析男性和女性AIS患者的危险因素，基线资料为肥胖和当前或既往吸烟史，吸烟,仅确定肥胖。主要预测因素和结果是与男性和女性AIS患者相关的危险因素。使用多变量回归分析对基线危险因素进行分析，以确定与肥胖和当前或先前吸烟史的联合影响相关的特定危险因素。
结果：目前或以前吸烟者的男性肥胖AIS患者更可能是老年患者（OR=1.024，95％CI，1.022-1.047，P=0.033），患有冠状动脉疾病（OR=1.806，95％CI，1.028-3.174，P=0.040），饮酒史(OR=2.873,95%CI,1.349-6.166,P=0.006),血肌酐升高(OR=4.724,95%CI,2.171~10.281,P<0.001),收缩压升高(OR=1.029,95%CI,1.011~1.047,P<0.002)。女性与抑郁的相关性更高(OR=0.432,95%CI,0.244-0.764,P=0.004),既往TIA（OR=0.319，95%CI，0.142-0.714，P<0.005），HDL水平较高(OR=0.938,95%CI,0.915-0.962,P<0.001)。
结论：我们的研究结果揭示了目前或过去有吸烟史的肥胖AIS患者危险因素的性别差异。这一发现强调需要制定管理策略，以改善目前或以前吸烟者的肥胖AIS患者的护理。
方法：回顾性分析男性和女性AIS患者的危险因素，基线资料为肥胖和当前或既往吸烟史，吸烟,仅确定肥胖。主要预测因素和结果是与男性和女性AIS患者相关的危险因素。使用多变量回归分析对基线危险因素进行分析，以确定与肥胖和当前或先前吸烟史的联合影响相关的特定危险因素。
结果：目前或以前吸烟者的男性肥胖AIS患者更可能是老年患者（OR=1.024，95％CI，1.022-1.047，P=0.033），患有冠状动脉疾病（OR=1.806，95％CI，1.028-3.174，P=0.040），饮酒史(OR=2.873,95%CI,1.349-6.166,P=0.006),血肌酐升高(OR=4.724,95%CI,2.171~10.281,P<0.001),收缩压升高(OR=1.029,95%CI,1.011~1.047,P<0.002)。女性与抑郁的相关性更高(OR=0.432,95%CI,0.244-0.764,P=0.004),既往TIA（OR=0.319，95%CI，0.142-0.714，P<0.005），HDL水平较高(OR=0.938,95%CI,0.915-0.962,P<0.001)。
结论：我们的研究结果揭示了目前或过去有吸烟史的肥胖AIS患者危险因素的性别差异。这一发现强调需要制定管理策略，以改善目前或以前吸烟者的肥胖AIS患者的护理。
