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Abstract：
OBJECTIVE: This study aimed to examine the impact of pertussis on the global, regional, and national levels between 1990 and 2019.
METHODS: Data on pertussis on a global scale from 1990 to 2019 were collected from the 2019 Global Burden of Disease Study. We performed a secondary analysis to report the global epidemiology and disease burden of pertussis.
RESULTS: During the period spanning from 1990 to 2019, pertussis exhibited a steady global decline in the age-standardized incidence rate (ASIR), age-standardized disability-adjusted life years rate (ASYR), and age-standardized death rate (ASDR). Nevertheless, upon delving into an in-depth analysis of various regions, it was apparent that ASIR in southern sub-Saharan Africa, ASYR and ASDR in high-income North America, and ASDR in Western Europe and Australasia, were witnessing an upward trajectory. Moreover, a negative correlation was observed between the Socio‑demographic Index (SDI) and burden inflicted by pertussis. Notably, the incidence of pertussis was comparatively lower in men than in women, with 0-4-year-olds emerging as the most profoundly affected demographic.
CONCLUSIONS: The global pertussis burden decreased from 1990 to 2019. However, certain regions and countries faced an increasing disease burden. Therefore, urgent measures are required to alleviate the pertussis burden in these areas.
METHODS: Data on pertussis on a global scale from 1990 to 2019 were collected from the 2019 Global Burden of Disease Study. We performed a secondary analysis to report the global epidemiology and disease burden of pertussis.
RESULTS: During the period spanning from 1990 to 2019, pertussis exhibited a steady global decline in the age-standardized incidence rate (ASIR), age-standardized disability-adjusted life years rate (ASYR), and age-standardized death rate (ASDR). Nevertheless, upon delving into an in-depth analysis of various regions, it was apparent that ASIR in southern sub-Saharan Africa, ASYR and ASDR in high-income North America, and ASDR in Western Europe and Australasia, were witnessing an upward trajectory. Moreover, a negative correlation was observed between the Socio‑demographic Index (SDI) and burden inflicted by pertussis. Notably, the incidence of pertussis was comparatively lower in men than in women, with 0-4-year-olds emerging as the most profoundly affected demographic.
CONCLUSIONS: The global pertussis burden decreased from 1990 to 2019. However, certain regions and countries faced an increasing disease burden. Therefore, urgent measures are required to alleviate the pertussis burden in these areas.
摘要：
目的：本研究旨在探讨百日咳对全球、区域,和1990年至2019年的全国水平。
方法：1990年至2019年全球范围的百日咳数据收集自2019年全球疾病负担研究。我们进行了二次分析，以报告百日咳的全球流行病学和疾病负担。
结果：在1990年至2019年期间，百日咳的年龄标准化发病率（ASIR）在全球范围内稳步下降，年龄标准化残疾调整寿命年率(ASYR)，和年龄标准化死亡率（ASDR）。然而，在对不同地区进行深入分析后，很明显，撒哈拉以南非洲南部的ASIR，高收入北美的ASYR和ASDR，和ASDR在西欧和澳大拉西亚，正在目睹一条向上的轨迹。此外，社会人口指数（SDI）与百日咳造成的负担之间呈负相关。值得注意的是,男性的百日咳发病率相对低于女性，0-4岁儿童成为受影响最严重的人口。
结论：从1990年到2019年，全球百日咳负担下降。然而,某些地区和国家面临着日益增加的疾病负担。因此,需要采取紧急措施来减轻这些地区的百日咳负担。
方法：1990年至2019年全球范围的百日咳数据收集自2019年全球疾病负担研究。我们进行了二次分析，以报告百日咳的全球流行病学和疾病负担。
结果：在1990年至2019年期间，百日咳的年龄标准化发病率（ASIR）在全球范围内稳步下降，年龄标准化残疾调整寿命年率(ASYR)，和年龄标准化死亡率（ASDR）。然而，在对不同地区进行深入分析后，很明显，撒哈拉以南非洲南部的ASIR，高收入北美的ASYR和ASDR，和ASDR在西欧和澳大拉西亚，正在目睹一条向上的轨迹。此外，社会人口指数（SDI）与百日咳造成的负担之间呈负相关。值得注意的是,男性的百日咳发病率相对低于女性，0-4岁儿童成为受影响最严重的人口。
结论：从1990年到2019年，全球百日咳负担下降。然而,某些地区和国家面临着日益增加的疾病负担。因此,需要采取紧急措施来减轻这些地区的百日咳负担。
