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Abstract：
OBJECTIVE: This study aimed to analyse the current status, trends and risk factors of disease burden from 1990 to 2019 among Chinese children.
METHODS: It was a retrospective study on data from the Global Burden of Disease Study 2019 (GBD 2019). Data of disease burden and risk factors were extracted from the GBD 2019. Children were divided into two groups of <5 and 5-14 years. Data were analysed using GBD results query tool, Excel and Pareto analysis.
METHODS: Disability-Adjusted Life Years (DALYs) and deaths.
RESULTS: The overall disease burden for both children <5 years and those aged 5-14 years significantly decreased from 1990 to 2019. For children aged <5 years, in 2019, the leading cause of deaths and DALYs were \'neonatal disorders\', and the top risk factor was \'low birth weight\'. Compared with data of 1990, the ranking of causes of deaths and DALYs in 2019 saw the most significant increase for \'HIV/AIDS and sexually transmitted infections\' and \'skin and subcutaneous diseases\' respectively. Conversely, the ranking of deaths/DALYs causes that dropped most significantly was \'nutritional deficiencies\'. For children aged 5-14, in 2019, the leading deaths and DALYs causes were \'unintentional injuries\' and \'mental disorders\' respectively. The top risk factors were \'alcohol use\' and \'short gestation\', respectively. The ranking of deaths and DALYs causes rose most significantly were \'HIV/AIDS and sexually transmitted infections\' and \'neonatal disorders\', respectively. Conversely, the ranking of deaths causes that dropped most significantly were \'other infectious diseases\', \'enteric infections\' and \'nutritional deficiencies\'. For DALYs, the causes that dropped most significantly in ranking were \'other infectious diseases\'.
CONCLUSIONS: The disease burden of children has significantly changed from 1990 to 2019, with notable differences between children aged <5 and 5-14 years. To optimise the allocation of health resources, it is necessary to adjust management strategies based on the latest disease burden.
METHODS: It was a retrospective study on data from the Global Burden of Disease Study 2019 (GBD 2019). Data of disease burden and risk factors were extracted from the GBD 2019. Children were divided into two groups of <5 and 5-14 years. Data were analysed using GBD results query tool, Excel and Pareto analysis.
METHODS: Disability-Adjusted Life Years (DALYs) and deaths.
RESULTS: The overall disease burden for both children <5 years and those aged 5-14 years significantly decreased from 1990 to 2019. For children aged <5 years, in 2019, the leading cause of deaths and DALYs were \'neonatal disorders\', and the top risk factor was \'low birth weight\'. Compared with data of 1990, the ranking of causes of deaths and DALYs in 2019 saw the most significant increase for \'HIV/AIDS and sexually transmitted infections\' and \'skin and subcutaneous diseases\' respectively. Conversely, the ranking of deaths/DALYs causes that dropped most significantly was \'nutritional deficiencies\'. For children aged 5-14, in 2019, the leading deaths and DALYs causes were \'unintentional injuries\' and \'mental disorders\' respectively. The top risk factors were \'alcohol use\' and \'short gestation\', respectively. The ranking of deaths and DALYs causes rose most significantly were \'HIV/AIDS and sexually transmitted infections\' and \'neonatal disorders\', respectively. Conversely, the ranking of deaths causes that dropped most significantly were \'other infectious diseases\', \'enteric infections\' and \'nutritional deficiencies\'. For DALYs, the causes that dropped most significantly in ranking were \'other infectious diseases\'.
CONCLUSIONS: The disease burden of children has significantly changed from 1990 to 2019, with notable differences between children aged <5 and 5-14 years. To optimise the allocation of health resources, it is necessary to adjust management strategies based on the latest disease burden.
摘要：
目的：本研究旨在分析研究现状，1990-2019年中国儿童疾病负担变化趋势及危险因素分析。
方法：这是一项对2019年全球疾病负担研究（GBD2019）数据的回顾性研究。疾病负担和危险因素的数据来自GBD2019。将儿童分为<5和5-14岁的两组。使用GBD结果查询工具对数据进行分析，Excel和帕累托分析。
方法：残疾调整寿命年(DALYs)和死亡。
结果：从1990年到2019年，<5岁儿童和5-14岁儿童的总体疾病负担显着下降。对于5岁以下的儿童，2019年，死亡和DALY的主要原因是“新生儿疾病”，最大的危险因素是“低出生体重”。与1990年的数据相比，2019年的死亡原因和DALY排名分别为“艾滋病毒/艾滋病和性传播感染”和“皮肤和皮下疾病”。相反，死亡/DALY原因的排名下降最明显的是“营养缺乏”。对于5-14岁的儿童，2019年，主要的死亡原因和DALY原因分别是“意外伤害”和“精神障碍”。最危险的因素是“饮酒”和“妊娠时间短”，分别。死亡和DALY原因排名上升最显著的是“艾滋病毒/艾滋病和性传播感染”和“新生儿疾病”，分别。相反，下降最明显的死亡原因排名是“其他传染病”，\'肠道感染\'和\'营养缺乏\'。对于DALYs，排名下降最明显的原因是“其他传染病”。
结论：1990-2019年儿童疾病负担发生了显著变化，<5岁和5-14岁儿童之间存在显著差异。优化卫生资源配置,有必要根据最新的疾病负担调整管理策略。
方法：这是一项对2019年全球疾病负担研究（GBD2019）数据的回顾性研究。疾病负担和危险因素的数据来自GBD2019。将儿童分为<5和5-14岁的两组。使用GBD结果查询工具对数据进行分析，Excel和帕累托分析。
方法：残疾调整寿命年(DALYs)和死亡。
结果：从1990年到2019年，<5岁儿童和5-14岁儿童的总体疾病负担显着下降。对于5岁以下的儿童，2019年，死亡和DALY的主要原因是“新生儿疾病”，最大的危险因素是“低出生体重”。与1990年的数据相比，2019年的死亡原因和DALY排名分别为“艾滋病毒/艾滋病和性传播感染”和“皮肤和皮下疾病”。相反，死亡/DALY原因的排名下降最明显的是“营养缺乏”。对于5-14岁的儿童，2019年，主要的死亡原因和DALY原因分别是“意外伤害”和“精神障碍”。最危险的因素是“饮酒”和“妊娠时间短”，分别。死亡和DALY原因排名上升最显著的是“艾滋病毒/艾滋病和性传播感染”和“新生儿疾病”，分别。相反，下降最明显的死亡原因排名是“其他传染病”，\'肠道感染\'和\'营养缺乏\'。对于DALYs，排名下降最明显的原因是“其他传染病”。
结论：1990-2019年儿童疾病负担发生了显著变化，<5岁和5-14岁儿童之间存在显著差异。优化卫生资源配置,有必要根据最新的疾病负担调整管理策略。
