Abstract：
The escalating threat of antimicrobial resistance (AMR) poses a grave concern to global public health, exacerbated by the alarming shortage of effective antibiotics in the pipeline. Biofilms, intricate populations of bacteria encased in self-produced matrices, pose a significant challenge to treatment, as they enhance resistance to antibiotics and contribute to the persistence of organisms. Amid these challenges, nanotechnology emerges as a promising domain in the fight against biofilms. Nanomaterials, with their unique properties at the nanoscale, offer innovative antibacterial modalities not present in traditional defensive mechanisms. This comprehensive review focuses on the potential of nanotechnology in combating biofilms, focusing on green-synthesized nanoparticles and their associated anti-biofilm potential. The review encompasses various aspects of nanoparticle-mediated biofilm inhibition, including mechanisms of action. The diverse mechanisms of action of green-synthesized nanoparticles offer valuable insights into their potential applications in addressing AMR and improving treatment outcomes, highlighting novel strategies in the ongoing battle against infectious diseases.
摘要：
抗菌素耐药性（AMR）的威胁不断升级，对全球公共卫生构成了严重关切。管道中有效抗生素的惊人短缺加剧了这种情况。生物膜,包裹在自产基质中的复杂细菌种群，对治疗构成重大挑战，因为它们增强了对抗生素的抵抗力，并有助于生物体的持久性。在这些挑战中，纳米技术成为对抗生物膜的一个有前途的领域。纳米材料,它们在纳米尺度上的独特特性，提供传统防御机制中不存在的创新抗菌方式。这篇全面的综述侧重于纳米技术在对抗生物膜方面的潜力，专注于绿色合成的纳米粒子及其相关的抗生物膜潜力。该综述涵盖了纳米颗粒介导的生物膜抑制的各个方面，包括行动机制。绿色合成纳米粒子的多种作用机制为其在解决AMR和改善治疗结果方面的潜在应用提供了有价值的见解。在与传染病的持续斗争中强调新的策略。
