Abstract：
The metabolic reconfiguration of tumor cells constitutes a pivotal aspect of tumor proliferation and advancement. This study delves into two primary facets of tumor metabolism: the Warburg effect and mitochondrial metabolism, elucidating their contributions to tumor dominance. The Warburg effect facilitates efficient energy acquisition by tumor cells through aerobic glycolysis and lactic acid fermentation, offering metabolic advantages conducive to growth and proliferation. Simultaneously, mitochondrial metabolism, serving as the linchpin of sustained tumor vitality, orchestrates the tricarboxylic acid cycle and electron transport chain, furnishing a steadfast and dependable wellspring of biosynthesis for tumor cells. Regarding targeted therapy, this discourse examines extant strategies targeting tumor glycolysis and mitochondrial metabolism, underscoring their potential efficacy in modulating tumor metabolism while envisaging future research trajectories and treatment paradigms in the realm of tumor metabolism. By means of a thorough exploration of tumor metabolism, this study aspires to furnish crucial insights into the regulation of tumor metabolic processes, thereby furnishing valuable guidance for the development of novel therapeutic modalities. This comprehensive deliberation is poised to catalyze advancements in tumor metabolism research and offer novel perspectives and pathways for the formulation of cancer treatment strategies in the times ahead.
摘要：
肿瘤细胞的代谢重构构成了肿瘤增殖和发展的关键方面。这项研究探讨了肿瘤代谢的两个主要方面：Warburg效应和线粒体代谢，阐明它们对肿瘤优势的贡献。Warburg效应通过有氧糖酵解和乳酸发酵促进肿瘤细胞的有效能量获取，提供有利于生长和增殖的代谢优势。同时,线粒体代谢，作为持续肿瘤活力的关键，协调三羧酸循环和电子传输链，为肿瘤细胞提供稳定可靠的生物合成能源。关于靶向治疗,本文探讨了针对肿瘤糖酵解和线粒体代谢的现有策略，强调它们在调节肿瘤代谢方面的潜在功效，同时设想肿瘤代谢领域的未来研究轨迹和治疗范例。通过对肿瘤代谢的深入探索，这项研究旨在为肿瘤代谢过程的调节提供重要的见解，从而为开发新的治疗方式提供有价值的指导。这一全面的审议有望促进肿瘤代谢研究的进步，并为未来癌症治疗策略的制定提供新的视角和途径。
