Abstract：
OBJECTIVE: Worldwide, incidence of thyroid malignancy is increasing. The purpose of this study was to evaluate the pattern and magnitude of nodule types.
METHODS: A cross-sectional retrospective study was performed at Saint Paul\'s Hospital Millennium Medical College, Addis Ababa, Ethiopia, among patients who underwent thyroidectomy from May 2018 to June 2022. Data were extracted using a structured format. Descriptive statistics were performed using SPSS version 26 software. Results were presented in terms of percentages and frequencies.
RESULTS: During a 4-year period, 1,476 patients had thyroidectomies and histopathologic information of 212 malignant cases was studied. Within multinodular goiter (MNG), thyroid cancer accounted for 69.8% (n = 148) of patients, whereas in solitary nodules, it accounted for 30.2%. From the total, 160 participants (75.5%) were female, and the female:male ratio was 3.1 (mean, 41.72; ± standard deviation [SD], 16.44) years, and age range of 12-88 years versus men, who have a mean of 44.71 (±SD, 14.91) years and an age range of 21-78 years. The mean age of male cases with solitary nodule and MNG was 40.6 and 46.5 years, respectively. The most frequent cancer in both types of nodules, accounting for 59% of patients, was papillary carcinoma, which was found in 64% of solitary nodules and 57.4% of multinodular nodules. Overall, 14.1% of tumors had multiple centers (17.4% in multinodular nodules and 6.9% in solitary nodules). In 7.1% of patients, microcarcinoma (<1 cm) was found, with papillary carcinoma accounting for 91.7% of the total.
CONCLUSIONS: Compared with men, women with cancer typically manifested at a younger age. Males with malignancy in solitary nodules had a lower mean age than those with MNGs. The most frequent and significant cause of multicentric presentation is papillary carcinoma.
METHODS: A cross-sectional retrospective study was performed at Saint Paul\'s Hospital Millennium Medical College, Addis Ababa, Ethiopia, among patients who underwent thyroidectomy from May 2018 to June 2022. Data were extracted using a structured format. Descriptive statistics were performed using SPSS version 26 software. Results were presented in terms of percentages and frequencies.
RESULTS: During a 4-year period, 1,476 patients had thyroidectomies and histopathologic information of 212 malignant cases was studied. Within multinodular goiter (MNG), thyroid cancer accounted for 69.8% (n = 148) of patients, whereas in solitary nodules, it accounted for 30.2%. From the total, 160 participants (75.5%) were female, and the female:male ratio was 3.1 (mean, 41.72; ± standard deviation [SD], 16.44) years, and age range of 12-88 years versus men, who have a mean of 44.71 (±SD, 14.91) years and an age range of 21-78 years. The mean age of male cases with solitary nodule and MNG was 40.6 and 46.5 years, respectively. The most frequent cancer in both types of nodules, accounting for 59% of patients, was papillary carcinoma, which was found in 64% of solitary nodules and 57.4% of multinodular nodules. Overall, 14.1% of tumors had multiple centers (17.4% in multinodular nodules and 6.9% in solitary nodules). In 7.1% of patients, microcarcinoma (<1 cm) was found, with papillary carcinoma accounting for 91.7% of the total.
CONCLUSIONS: Compared with men, women with cancer typically manifested at a younger age. Males with malignancy in solitary nodules had a lower mean age than those with MNGs. The most frequent and significant cause of multicentric presentation is papillary carcinoma.
摘要：
目标：全球，甲状腺恶性肿瘤的发病率正在增加。这项研究的目的是评估结节类型的模式和大小。
方法：在圣保罗医院千年医学院进行了一项横断面回顾性研究，亚的斯亚贝巴,埃塞俄比亚,在2018年5月至2022年6月期间接受甲状腺切除术的患者中.使用结构化格式提取数据。使用SPSS版本26软件进行描述性统计。结果以百分比和频率表示。
结果：在4年期间，1,476例患者进行了甲状腺切除术，并研究了212例恶性病例的组织病理学信息。在多结节性甲状腺肿(MNG)内，甲状腺癌占69.8%(n=148),而在孤立结节中，占30.2%。从总数来看，160名参与者（75.5%）为女性，女性：男性比例为3.1(平均值，41.72；±标准偏差[SD]，16.44）年，与男性相比，年龄范围为12-88岁，平均值为44.71(±SD，14.91）岁，年龄范围为21-78岁。单发结节和MNG的男性患者平均年龄为40.6岁和46.5岁，分别。这两种类型的结节中最常见的癌症，占59%的患者，是乳头状癌，在64％的孤立结节和57.4％的多结节中发现。总的来说,14.1％的肿瘤有多个中心（多结节结节为17.4％，孤立结节为6.9％）。在7.1%的患者中，发现微小癌（<1厘米），乳头状癌占总数的91.7%。
结论：与男性相比，患有癌症的女性通常表现在年轻的时候。孤立结节中恶性肿瘤的男性的平均年龄低于MNG的男性。多中心表现的最常见和最重要的原因是乳头状癌。
方法：在圣保罗医院千年医学院进行了一项横断面回顾性研究，亚的斯亚贝巴,埃塞俄比亚,在2018年5月至2022年6月期间接受甲状腺切除术的患者中.使用结构化格式提取数据。使用SPSS版本26软件进行描述性统计。结果以百分比和频率表示。
结果：在4年期间，1,476例患者进行了甲状腺切除术，并研究了212例恶性病例的组织病理学信息。在多结节性甲状腺肿(MNG)内，甲状腺癌占69.8%(n=148),而在孤立结节中，占30.2%。从总数来看，160名参与者（75.5%）为女性，女性：男性比例为3.1(平均值，41.72；±标准偏差[SD]，16.44）年，与男性相比，年龄范围为12-88岁，平均值为44.71(±SD，14.91）岁，年龄范围为21-78岁。单发结节和MNG的男性患者平均年龄为40.6岁和46.5岁，分别。这两种类型的结节中最常见的癌症，占59%的患者，是乳头状癌，在64％的孤立结节和57.4％的多结节中发现。总的来说,14.1％的肿瘤有多个中心（多结节结节为17.4％，孤立结节为6.9％）。在7.1%的患者中，发现微小癌（<1厘米），乳头状癌占总数的91.7%。
结论：与男性相比，患有癌症的女性通常表现在年轻的时候。孤立结节中恶性肿瘤的男性的平均年龄低于MNG的男性。多中心表现的最常见和最重要的原因是乳头状癌。
