PDF(Pubmed)
Abstract：
BACKGROUND The healing of bone defects is a serious challenge worldwide. One branch of dentistry deals with bone defects. Capsaicin has anti-inflammatory, anti-oxidative, and cholesterol-reducing effects. The aim of this study was to evaluate the effects of systemic capsaicin administered at different doses on bone healing. MATERIAL AND METHODS A total of 32 male wistar rats was used, their weight varying between 250 and 300 g. The rats were randomly divided into 4 groups of 8 rats each. The analyses served to evaluate the effect on healing of different doses of capsaicin and grafts. A significant increase was observed in the number of osteoblasts in the capsaicin-applied groups, compared with the control group. RESULTS The analyses served to evaluate the effect on healing of different doses of capsaicin and grafts. A significant increase was observed in the number of osteoblasts in the capsaicin-applied groups, compared with that of the control group. The inflammation scores showed a significant difference only in the control group and in the group administered with 50 mg/kg capsaicin (P=0.010). The osteoclast counts were significantly different between all groups. CONCLUSIONS As a result of the analyses, positive effects on bone healing were observed when capsaicin 0.25 mg/kg and 0.50 mg/kg was administered intraperitoneally. However, more studies are needed for more accurate information.
摘要：
背景技术骨缺损的愈合是世界范围内的严峻挑战。牙科的一个分支处理骨缺损。辣椒素有消炎作用,抗氧化，和降低胆固醇的作用。这项研究的目的是评估不同剂量的全身辣椒素对骨骼愈合的影响。材料和方法共使用32只雄性Wistar大鼠，它们的体重在250和300克之间变化。将大鼠随机分成4组,每组8只大鼠。分析用于评估不同剂量的辣椒素和移植物对愈合的影响。辣椒素应用组的成骨细胞数量显着增加，与对照组相比。结果这些分析用于评估不同剂量的辣椒素和移植物对愈合的影响。辣椒素应用组的成骨细胞数量显着增加，与对照组相比。炎症评分仅在对照组和给予50mg/kg辣椒素的组中显示出显著差异(P=0.010)。所有组之间的破骨细胞计数显着不同。结论作为分析的结果，当腹膜内给予辣椒素0.25mg/kg和0.50mg/kg时，观察到对骨愈合的积极作用。然而,需要更多的研究来获得更准确的信息。
