Abstract：
Radiotherapy commonly causes damage to healthy tissues, particularly radiation-induced skin injury (RISI) that affects a significant majority of patients undergoing radiotherapy. Effective treatments for RISI are lacking. This study focuses on the pathogenesis of RISI, which primarily involves oxidative stress. Excessive reactive oxygen species (ROS) generation during radiation induces damage to biological macromolecules, triggering oxidative stress and inflammation. To address this, ergothioneine (EGT), a natural and biocompatibile thiol compound with excellent antioxidant activity, is explored as a potential radiation-protective agent. By utilizing its specific transport and absorption in the skin tissue, as well as its efficient and stable clearance of radiation-induced \"ROS storm\", EGT is combined with sodium hyaluronate (NaHA) to develop a novel radiation protective dressing suitable for the skin. This EGT-NaHA dressing demonstrates an effective ability to scavenge free radicals and reduce oxidative stress in vitro and in vivo, reducing cellular apoptosis and inflammation. These results demonstrate the protective properties of EGT against RISI, with far-reaching implications for research and development in the field of radioprotection.
摘要：
放射治疗通常会对健康组织造成损害，特别是辐射引起的皮肤损伤（RISI），影响了绝大多数接受放射治疗的患者。缺乏有效的RISI治疗方法。本研究集中于RISI的发病机制，主要涉及氧化应激。辐射过程中产生过量的活性氧（ROS）会导致生物大分子受损，引发氧化应激和炎症。为了解决这个问题，麦角硫因(EGT),一种具有优异抗氧化活性的天然生物相容性硫醇化合物，作为一种潜在的辐射防护剂。通过利用其在皮肤组织中的特定运输和吸收，以及它对辐射引起的“ROS风暴”的有效和稳定的清除，EGT与透明质酸钠(NaHA)组合以开发适用于皮肤的新型辐射防护敷料。这种EGT-NaHA敷料证明了在体外和体内清除自由基和减少氧化应激的有效能力，减少细胞凋亡和炎症。这些结果证明了EGT对RISI的保护特性，对辐射防护领域的研究和发展具有深远的意义。
