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Abstract：
Rickettsia africae is a tick-borne bacteria known to cause African tick bite fever (ATBF). While the disease was first described more than 100 years ago, knowledge of transmission risk factors and disease burden remain poorly described. To better understand the burden of R. africae, this article reviewed and summarized the published literature related to ATBF epidemiology and clinical management. Using a systematic approach, consistent with the PRISMA guidelines, we identified more than 100 eligible articles, including 65 epidemiological studies and 41 case reports. Most reports described R. africae in ticks and livestock, while human studies were less common. Human disease case reports were exclusively among returning travellers from non-endemic areas, which limits our disease knowledge among at-risk populations: people living in endemic regions. Substantial efforts to elucidate the ATBF risk factors and clinical manifestations among local populations are needed to develop effective preventative strategies and facilitate appropriate and timely diagnosis.
摘要：
非洲立克次体是一种蜱传播的细菌，已知会引起非洲蜱叮咬热（ATBF）。虽然这种疾病在100多年前首次被描述，对传播危险因素和疾病负担的了解仍然很少。为了更好地了解非洲毛虫的负担，本文对已发表的与ATBF流行病学和临床管理相关的文献进行了回顾和总结。使用系统的方法，与PRISMA准则一致，我们确定了100多篇符合条件的文章，包括65项流行病学研究和41例病例报告。大多数报道描述了蜱和牲畜中的非洲R。而人类研究并不常见。人类疾病病例报告仅来自非流行地区的返回旅行者，这限制了我们在高危人群中的疾病知识：生活在流行地区的人们。需要大量努力阐明当地人群中的ATBF危险因素和临床表现，以制定有效的预防策略并促进适当和及时的诊断。
