PDF(Pubmed)
Abstract：
UNASSIGNED: Cupressus sempervirens is a tree native to the Mediterranean region. We aimed to investigate the frequency of sensitization/allergy to Cupressus arizonica pollen, which is not native to Anatolia.
UNASSIGNED: Patients aged 5-18 years who underwent respiratory allergy screening in Türkiye\'s largest referral center over a 1-year period were reviewed retrospectively for a diagnostic study of Cupressus allergy.
UNASSIGNED: Of 246 patients, 207 (67.6% male) with a median age of 11.7 (IQR 9.2-15) years were found to be aeroallergen-sensitive and C. arizonica (32%) was the second most common sensitivity after grass pollen (83.6%). In the C. arizonica-sensitive subgroup, only 3% (2/67) were monosensitive, and grass (77.6%), cat (38.8%), and weeds (38.8%) were the most common co-sensitivities. Cup a 1 specific IgE (sIgE) was measured in 26 patients with C. arizonica sensitivity and all were found to be positive. A nasal allergen challenge (NAC) was performed for 44 of 67 patients with C. arizonica sensitivity, and 13 of 44 patients had a positive outcome (NAC+) at the highest two extract concentrations. The Cupressus wheal sizes and Cup a 1 sIgE levels of the NAC+ subgroup were higher than those of the NAC- subgroup but reached significance only for wheal size [6 (5-7.5) vs. 4.5 (4-6), p=0.004]. The NAC+ subgroup reported more frequent nasal discharge, congestion, and eye symptoms than the NAC- subgroup during the relevant pollen season.
UNASSIGNED: C. arizonica sensitivity has increased in the East Mediterranean region, similarly to North Mediterranean data, and this is associated with the presence of allergy both clinically and in laboratory findings. C. arizonica should be included in the aeroallergen screening panels of children from the East Mediterranean.
UNASSIGNED: Patients aged 5-18 years who underwent respiratory allergy screening in Türkiye\'s largest referral center over a 1-year period were reviewed retrospectively for a diagnostic study of Cupressus allergy.
UNASSIGNED: Of 246 patients, 207 (67.6% male) with a median age of 11.7 (IQR 9.2-15) years were found to be aeroallergen-sensitive and C. arizonica (32%) was the second most common sensitivity after grass pollen (83.6%). In the C. arizonica-sensitive subgroup, only 3% (2/67) were monosensitive, and grass (77.6%), cat (38.8%), and weeds (38.8%) were the most common co-sensitivities. Cup a 1 specific IgE (sIgE) was measured in 26 patients with C. arizonica sensitivity and all were found to be positive. A nasal allergen challenge (NAC) was performed for 44 of 67 patients with C. arizonica sensitivity, and 13 of 44 patients had a positive outcome (NAC+) at the highest two extract concentrations. The Cupressus wheal sizes and Cup a 1 sIgE levels of the NAC+ subgroup were higher than those of the NAC- subgroup but reached significance only for wheal size [6 (5-7.5) vs. 4.5 (4-6), p=0.004]. The NAC+ subgroup reported more frequent nasal discharge, congestion, and eye symptoms than the NAC- subgroup during the relevant pollen season.
UNASSIGNED: C. arizonica sensitivity has increased in the East Mediterranean region, similarly to North Mediterranean data, and this is associated with the presence of allergy both clinically and in laboratory findings. C. arizonica should be included in the aeroallergen screening panels of children from the East Mediterranean.
摘要：
■柏树是地中海地区的一种树。我们的目的是调查对阿拉伯柏树花粉致敏/过敏的频率，这不是安纳托利亚的本地人。
■在Türkiye最大的转诊中心接受呼吸道过敏筛查的5-18岁患者在1年的时间内进行了回顾性分析，以进行一项柏氏变态反应的诊断研究。
■在246名患者中，207（67.6％的男性），中位年龄为11.7（IQR9.2-15）岁，对空气过敏原敏感，而C.arizonica（32％）是仅次于草花粉（83.6％）的第二大最常见的敏感性。在阿拉伯念珠菌敏感亚组中，只有3%(2/67)是单敏感的，和草(77.6%)，猫（38.8%），和杂草(38.8%)是最常见的共敏感性。在26例具有C.arizonica敏感性的患者中测量了Cupa1特异性IgE（sIgE），所有患者均为阳性。对67例具有阿拉伯念珠菌敏感性的患者中的44例进行了鼻过敏原攻击（NAC），44例患者中的13例患者在最高的两种提取物浓度下具有阳性结果(NAC+)。NAC+亚组的Cupressus囊大小和Cupa1sIgE水平高于NAC-亚组，但仅在囊大小[6（5-7.5）与4.5(4-6)、p=0.004]。NAC+亚组报告更频繁的流鼻涕，拥塞，在相关的花粉季节，眼睛症状比NAC-亚组。
■C.东地中海地区对亚利桑那州的敏感性有所提高，类似于北地中海的数据，这与临床和实验室发现的过敏有关。加拿大应包括在东地中海儿童的空气过敏原筛查小组中。
■在Türkiye最大的转诊中心接受呼吸道过敏筛查的5-18岁患者在1年的时间内进行了回顾性分析，以进行一项柏氏变态反应的诊断研究。
■在246名患者中，207（67.6％的男性），中位年龄为11.7（IQR9.2-15）岁，对空气过敏原敏感，而C.arizonica（32％）是仅次于草花粉（83.6％）的第二大最常见的敏感性。在阿拉伯念珠菌敏感亚组中，只有3%(2/67)是单敏感的，和草(77.6%)，猫（38.8%），和杂草(38.8%)是最常见的共敏感性。在26例具有C.arizonica敏感性的患者中测量了Cupa1特异性IgE（sIgE），所有患者均为阳性。对67例具有阿拉伯念珠菌敏感性的患者中的44例进行了鼻过敏原攻击（NAC），44例患者中的13例患者在最高的两种提取物浓度下具有阳性结果(NAC+)。NAC+亚组的Cupressus囊大小和Cupa1sIgE水平高于NAC-亚组，但仅在囊大小[6（5-7.5）与4.5(4-6)、p=0.004]。NAC+亚组报告更频繁的流鼻涕，拥塞，在相关的花粉季节，眼睛症状比NAC-亚组。
■C.东地中海地区对亚利桑那州的敏感性有所提高，类似于北地中海的数据，这与临床和实验室发现的过敏有关。加拿大应包括在东地中海儿童的空气过敏原筛查小组中。
