PDF(Pubmed)
Abstract：
Nattokinase (NK) and red yeast rice (RYR) are both indicated for their potential in cardiovascular disease prevention and management, but their combined effects especially in coronary artery disease (CAD) are scarcely examined. This 90-day randomized, double-blind trial aims to investigate the effect of NK and RYR supplementations on cardiometabolic parameters in patients with stable CAD. 178 CAD patients were randomized to four groups: NK + RYR, NK, RYR, and placebo. No adverse effects due to the interventions were reported. In comparisons across groups, NK + RYR showed the maximum effect in reducing triglyceride (-0.39 mmol), total cholesterol (-0.66 mmol/L), diastolic blood pressure (-7.39 mmHg), and increase in high-density lipoprotein cholesterol (0.195 mmol/L) than other groups (all p for multiple groups comparison<0.01). Both NK + RYR and NK groups had significantly better-improved lactate dehydrogenase than the others (-29.1 U/L and - 26.4 U/L). NK + RYR group also showed more potent reductions in thromboxane B2 and increases in antithrombin III compared to placebo (both p < 0.01). These improved markers suggest that combined NK and RYR may preferably alter antithrombin and COX-1 pathways, potentially reducing thrombosis risks in CAD patients. Overall, the combined NK and RYR supplementation is safe and more effective than separately in improving cardiometabolic markers among CAD patients with multiple heart medications use.
摘要：
纳豆激酶（NK）和红曲米（RYR）均具有预防和管理心血管疾病的潜力，但它们的综合作用，特别是在冠状动脉疾病（CAD）中，几乎没有检查。这个90天的随机分组，双盲试验旨在研究NK和RYR补充剂对稳定性CAD患者心脏代谢参数的影响.178例CAD患者随机分为四组：NK+RYR，NK,RYR,和安慰剂。没有报告由于干预措施引起的不良反应。在组间比较中，NK+RYR显示出最大的降低甘油三酯的作用（-0.39mmol），总胆固醇（-0.66mmol/L），舒张压（-7.39mmHg），高密度脂蛋白胆固醇(0.195mmol/L)高于其他组(均p为多组比较<0.01)。NK+RYR和NK组的乳酸脱氢酶均比其他组显著改善(-29.1U/L和-26.4U/L)。与安慰剂相比,NK+RYR组还显示出更有效的血栓素B2减少和抗凝血酶III增加(均p<0.01)。这些改善的标志物表明，结合NK和RYR可以优选地改变抗凝血酶和COX-1途径，有可能降低CAD患者的血栓形成风险。总的来说,在使用多种心脏药物的CAD患者中,NK和RYR联合补充在改善心脏代谢标志物方面比单独补充更安全和有效.
