PDF(Pubmed)
Abstract：
UNASSIGNED: Atopic dermatitis (AD) is an inflammatory, pruritic, noncontagious, chronic relapsing skin disease. Skin barrier abnormalities, excessive T helper 2 activity, and immune dysregulation are held responsible. Androgens have a negative effect on the integrity of the epidermal skin barrier, while estrogen has a positive effect. We aimed to investigate whether hormones make a difference between healthy children and children with AD during minipuberty.
UNASSIGNED: A total of 96 infants (postnatal 4-13 weeks), 48 diagnosed with AD and 48 controls, were included. Each group consisted of 23 girls (47.9%) and 25 boys (52.1%). Anthropometric examinations and hormone measurements were compared.
UNASSIGNED: The two groups, having similar age, sex, body mass index, and weight-for-length standard deviation scores, were compared. Serum free thyroxine (FT4) levels were found to be lower and insulin-like growth factor binding protein-3 (IGFBP3) levels were found to be higher in children with AD (p < 0.001 and p = 0.038, respectively). In girls with AD, estradiol, FT4, and insulin-like growth factor-1 (IGF-1) levels were found to be lower, but thyroid-stimulating hormone (TSH) levels were found to be higher (p = 0.023, p < 0.001, p = 0.038, and p = 0.034, respectively). In boys with AD, the FT4 level was found to be lower (p = 0.023). Serum FT4 and TSH levels were within normal reference ranges in all comparisons.
UNASSIGNED: Especially in girls with AD, decreased estradiol and IGF-1 levels were observed compared to the controls during minipuberty. In the logistic regression model, decreased levels of serum estradiol, dehydroepiandrosterone sulfate, FT4, and IGF-1, and increased levels of IGFBP3 were associated with an increased likelihood of exhibiting atopic dermatitis.
UNASSIGNED: A total of 96 infants (postnatal 4-13 weeks), 48 diagnosed with AD and 48 controls, were included. Each group consisted of 23 girls (47.9%) and 25 boys (52.1%). Anthropometric examinations and hormone measurements were compared.
UNASSIGNED: The two groups, having similar age, sex, body mass index, and weight-for-length standard deviation scores, were compared. Serum free thyroxine (FT4) levels were found to be lower and insulin-like growth factor binding protein-3 (IGFBP3) levels were found to be higher in children with AD (p < 0.001 and p = 0.038, respectively). In girls with AD, estradiol, FT4, and insulin-like growth factor-1 (IGF-1) levels were found to be lower, but thyroid-stimulating hormone (TSH) levels were found to be higher (p = 0.023, p < 0.001, p = 0.038, and p = 0.034, respectively). In boys with AD, the FT4 level was found to be lower (p = 0.023). Serum FT4 and TSH levels were within normal reference ranges in all comparisons.
UNASSIGNED: Especially in girls with AD, decreased estradiol and IGF-1 levels were observed compared to the controls during minipuberty. In the logistic regression model, decreased levels of serum estradiol, dehydroepiandrosterone sulfate, FT4, and IGF-1, and increased levels of IGFBP3 were associated with an increased likelihood of exhibiting atopic dermatitis.
摘要：
■特应性皮炎（AD）是一种炎症性，瘙痒,非传染性的，慢性复发性皮肤病。皮肤屏障异常,过度的T辅助细胞2活性，和免疫失调负责。雄激素对表皮皮肤屏障的完整性有负面影响，而雌激素有积极作用。我们的目的是调查激素是否在青春期健康儿童和AD儿童之间产生差异。
■总共96名婴儿（产后4-13周），48例诊断为AD和48例对照，包括在内。每组由23名女孩（47.9％）和25名男孩（52.1％）组成。比较人体测量检查和激素测量。
■两组,有相似的年龄，性别,身体质量指数,和体重长度标准差分数，进行了比较。发现AD患儿的血清游离甲状腺素（FT4）水平较低，胰岛素样生长因子结合蛋白3（IGFBP3）水平较高（分别为p<0.001和p=0.038）。在有AD的女孩中，雌二醇,发现FT4和胰岛素样生长因子-1（IGF-1）水平较低，但发现促甲状腺激素（TSH）水平较高（分别为p=0.023，p<0.001，p=0.038和p=0.034）。在有AD的男孩中，发现FT4水平较低(p=0.023)。在所有比较中,血清FT4和TSH水平在正常参考范围内。
■尤其是患有AD的女孩，与小青春期对照组相比，观察到雌二醇和IGF-1水平降低。在逻辑回归模型中，血清雌二醇水平降低，硫酸脱氢表雄酮，FT4和IGF-1以及IGFBP3水平的增加与表现特应性皮炎的可能性增加有关。
■总共96名婴儿（产后4-13周），48例诊断为AD和48例对照，包括在内。每组由23名女孩（47.9％）和25名男孩（52.1％）组成。比较人体测量检查和激素测量。
■两组,有相似的年龄，性别,身体质量指数,和体重长度标准差分数，进行了比较。发现AD患儿的血清游离甲状腺素（FT4）水平较低，胰岛素样生长因子结合蛋白3（IGFBP3）水平较高（分别为p<0.001和p=0.038）。在有AD的女孩中，雌二醇,发现FT4和胰岛素样生长因子-1（IGF-1）水平较低，但发现促甲状腺激素（TSH）水平较高（分别为p=0.023，p<0.001，p=0.038和p=0.034）。在有AD的男孩中，发现FT4水平较低(p=0.023)。在所有比较中,血清FT4和TSH水平在正常参考范围内。
■尤其是患有AD的女孩，与小青春期对照组相比，观察到雌二醇和IGF-1水平降低。在逻辑回归模型中，血清雌二醇水平降低，硫酸脱氢表雄酮，FT4和IGF-1以及IGFBP3水平的增加与表现特应性皮炎的可能性增加有关。
