PDF(Pubmed)
Abstract：
UNASSIGNED: Nocturnal enuresis can be frustrating for children and their families as the child ages. Our aim is to evaluate urine aquaporin 2 (AQP-2) as a noninvasive biomarker of water balance in children with primary monosymptomatic nocturnal enuresis (PMNE).
UNASSIGNED: The study included 90 children; sixty-eight children suffering from PMNE aged (9.57 ± 2.16) years and 22 healthy children with good toilet control, matched sex and age. All enuretic children were subjected to complete history taking, clinical evaluation, and bed wetting diary. Serum arginine vasopressin (AVP) and urine AQP-2 were tested in the morning (at 9-11 am) and evening (at 9-11 pm). Blood urea, creatinine, Na, glucose, urine osmolality, Ca/Cr, Alb/Cr and specific gravity were tested simultaneously.
UNASSIGNED: Serum AVP, urine AQP-2, and urine osmolality were statistically lower in patients than controls. Patients had a significantly lower level of night serum AVP concentrations, urine AQP-2, and urine osmolality than the corresponding morning level. Urine AQP-2 was significantly correlated with urine osmolality (p < 0.05). AQP-2 had a sensitivity of 90% and a specificity of 70%. However, no statistically significant correlation was found between serum AVP and urine AQP-2.
UNASSIGNED: Primary monosymptomatic nocturnal enuresis in children could be associated with reduction of urine excretion of AQP-2 at night. Urine AQP-2 is significantly correlated with urine osmolality. Therefore, it may be a noninvasive biomarker of hydration status in children with PMNE, with good sensitivity and specificity.
UNASSIGNED: The study included 90 children; sixty-eight children suffering from PMNE aged (9.57 ± 2.16) years and 22 healthy children with good toilet control, matched sex and age. All enuretic children were subjected to complete history taking, clinical evaluation, and bed wetting diary. Serum arginine vasopressin (AVP) and urine AQP-2 were tested in the morning (at 9-11 am) and evening (at 9-11 pm). Blood urea, creatinine, Na, glucose, urine osmolality, Ca/Cr, Alb/Cr and specific gravity were tested simultaneously.
UNASSIGNED: Serum AVP, urine AQP-2, and urine osmolality were statistically lower in patients than controls. Patients had a significantly lower level of night serum AVP concentrations, urine AQP-2, and urine osmolality than the corresponding morning level. Urine AQP-2 was significantly correlated with urine osmolality (p < 0.05). AQP-2 had a sensitivity of 90% and a specificity of 70%. However, no statistically significant correlation was found between serum AVP and urine AQP-2.
UNASSIGNED: Primary monosymptomatic nocturnal enuresis in children could be associated with reduction of urine excretion of AQP-2 at night. Urine AQP-2 is significantly correlated with urine osmolality. Therefore, it may be a noninvasive biomarker of hydration status in children with PMNE, with good sensitivity and specificity.
摘要：
■随着孩子年龄的增长，夜间遗尿症可能会让孩子及其家人感到沮丧。我们的目的是评估尿液水通道蛋白2（AQP-2）作为原发性单症状性夜间遗尿症（PMNE）儿童水平衡的非侵入性生物标志物。
■该研究包括90名儿童；68名年龄（9.57±2.16）岁的PMNE儿童和22名厕所控制良好的健康儿童，性别和年龄相匹配。所有的排尿儿童都接受了完整的病史记录，临床评估，还有尿床日记.在早晨（上午9-11点）和晚上（晚上9-11点）测试了血清精氨酸加压素（AVP）和尿液AQP-2。血尿素,肌酐,Na,葡萄糖，尿液渗透压,Ca/Cr,同时测试Alb/Cr和比重。
■血清AVP，患者的尿AQP-2和尿渗透压在统计学上低于对照组.患者夜间血清AVP浓度水平明显降低，尿液AQP-2，尿液渗透压高于相应的早晨水平。尿AQP-2与尿渗透压显著相关(p<0.05)。AQP-2的敏感性为90%,特异性为70%。然而,血清AVP与尿AQP-2无统计学相关性。
■儿童原发性单症状性夜间遗尿症可能与夜间尿AQP-2排泄减少有关。尿AQP-2与尿渗透压显著相关。因此,它可能是PMNE儿童水合状态的非侵入性生物标志物，具有良好的敏感性和特异性。
■该研究包括90名儿童；68名年龄（9.57±2.16）岁的PMNE儿童和22名厕所控制良好的健康儿童，性别和年龄相匹配。所有的排尿儿童都接受了完整的病史记录，临床评估，还有尿床日记.在早晨（上午9-11点）和晚上（晚上9-11点）测试了血清精氨酸加压素（AVP）和尿液AQP-2。血尿素,肌酐,Na,葡萄糖，尿液渗透压,Ca/Cr,同时测试Alb/Cr和比重。
■血清AVP，患者的尿AQP-2和尿渗透压在统计学上低于对照组.患者夜间血清AVP浓度水平明显降低，尿液AQP-2，尿液渗透压高于相应的早晨水平。尿AQP-2与尿渗透压显著相关(p<0.05)。AQP-2的敏感性为90%,特异性为70%。然而,血清AVP与尿AQP-2无统计学相关性。
■儿童原发性单症状性夜间遗尿症可能与夜间尿AQP-2排泄减少有关。尿AQP-2与尿渗透压显著相关。因此,它可能是PMNE儿童水合状态的非侵入性生物标志物，具有良好的敏感性和特异性。
