PDF(Pubmed)
Abstract：
OBJECTIVE: Methamphetamine use disorder (MUD) is a global health condition that impairs a person\'s health which may result in morbidity and mortality. Inflammation is a crucial process playing a vital role in MUD. For this reason, it is necessary to examine biochemical parameters for follow-up and treatment alternatives.
METHODS: We aimed to reveal the relationship between inflammatory response and MUD by evaluating peripheral hemogram parameters, leukocyte count, subtypes, and their ratios to each other, systemic immune inflammation index (SII), monocyte/high-density lipoprotein (HDL) ratio, and human C-reactive protein (CRP) in adult men with MUD. We included 76 adult male participants in the patient group and 70 adult male participants in the control group. We calculated the neutrophil/lymphocyte rate (NLR), monocyte/lymphocyte rate (MLR), platelet/lymphocyte rate (PLR), and basophil/lymphocyte rate (BLR). In addition, we obtained the SII and the monocyte/HDL rate.
RESULTS: The patients\' leukocyte (p<0.001), platelet (p<0.001), plateletcrit (PCT) (p=0.002), neutrophil (p<0.001), monocyte (p=0.002), CRP (p<0.001), NLR (p=0.001), PLR (p=0.004), MLR (p=0.009), SII (p<0.001) and monocyte/HDL ratio (p<0.001) were higher than the control group. We observed a significant and positive relationship between the daily methamphetamine intake, and methamphetamine use duration (p=0.002), PCT (p=0.044), neutrophil (p=0.021), NLR (p=0.001), PLR (p=0.004), MLR (p=0.029), and SII (p<0.001). Daily methamphetamine intake had a significant and positive effect on SII. A one-unit increase in daily methamphetamine intake elevated SII by 165.53 units.
CONCLUSIONS: The results confirm the presence of peripheral subclinical inflammation and systemic immune inflammation in adult men with MUD.
METHODS: We aimed to reveal the relationship between inflammatory response and MUD by evaluating peripheral hemogram parameters, leukocyte count, subtypes, and their ratios to each other, systemic immune inflammation index (SII), monocyte/high-density lipoprotein (HDL) ratio, and human C-reactive protein (CRP) in adult men with MUD. We included 76 adult male participants in the patient group and 70 adult male participants in the control group. We calculated the neutrophil/lymphocyte rate (NLR), monocyte/lymphocyte rate (MLR), platelet/lymphocyte rate (PLR), and basophil/lymphocyte rate (BLR). In addition, we obtained the SII and the monocyte/HDL rate.
RESULTS: The patients\' leukocyte (p<0.001), platelet (p<0.001), plateletcrit (PCT) (p=0.002), neutrophil (p<0.001), monocyte (p=0.002), CRP (p<0.001), NLR (p=0.001), PLR (p=0.004), MLR (p=0.009), SII (p<0.001) and monocyte/HDL ratio (p<0.001) were higher than the control group. We observed a significant and positive relationship between the daily methamphetamine intake, and methamphetamine use duration (p=0.002), PCT (p=0.044), neutrophil (p=0.021), NLR (p=0.001), PLR (p=0.004), MLR (p=0.029), and SII (p<0.001). Daily methamphetamine intake had a significant and positive effect on SII. A one-unit increase in daily methamphetamine intake elevated SII by 165.53 units.
CONCLUSIONS: The results confirm the presence of peripheral subclinical inflammation and systemic immune inflammation in adult men with MUD.
摘要：
目的：甲基苯丙胺使用障碍（MUD）是一种全球性的健康状况，损害一个人的健康，可能导致发病率和死亡率。炎症是在MUD中起重要作用的关键过程。出于这个原因,有必要检查生化参数以进行后续治疗和替代治疗。
方法：我们旨在通过评估外周血像参数来揭示炎症反应与MUD之间的关系，白细胞计数,亚型，以及它们之间的比例，全身免疫炎症指数（SII），单核细胞/高密度脂蛋白（HDL）比值，和人C反应蛋白（CRP）在成年男性MUD。我们包括76名成年男性参与者为患者组，70名成年男性参与者为对照组。我们计算了中性粒细胞/淋巴细胞比率（NLR），单核细胞/淋巴细胞比率（MLR），血小板/淋巴细胞率（PLR），和嗜碱性粒细胞/淋巴细胞比率（BLR）。此外,我们获得了SII和单核细胞/HDL率。
结果：患者白细胞（p<0.001），血小板（p<0.001），plateletcrit（PCT）（p=0.002），中性粒细胞（p<0.001），单核细胞（p=0.002），CRP（p<0.001），NLR（p=0.001），PLR（p=0.004），MLR（p=0.009），SII（p<0.001）和单核细胞/HDL比率（p<0.001）均高于对照组。我们观察到每天的甲基苯丙胺摄入量之间存在显着的正相关关系，和甲基苯丙胺的使用持续时间（p=0.002），PCT（p=0.044），中性粒细胞（p=0.021），NLR（p=0.001），PLR（p=0.004），MLR（p=0.029），和SII(p<0.001)。每日甲基苯丙胺摄入量对SII有显著的积极影响。每天甲基苯丙胺摄入量增加一个单位，SII就会增加165.53个单位。
结论：结果证实在MUD成年男性患者中存在外周亚临床炎症和全身免疫炎症。
方法：我们旨在通过评估外周血像参数来揭示炎症反应与MUD之间的关系，白细胞计数,亚型，以及它们之间的比例，全身免疫炎症指数（SII），单核细胞/高密度脂蛋白（HDL）比值，和人C反应蛋白（CRP）在成年男性MUD。我们包括76名成年男性参与者为患者组，70名成年男性参与者为对照组。我们计算了中性粒细胞/淋巴细胞比率（NLR），单核细胞/淋巴细胞比率（MLR），血小板/淋巴细胞率（PLR），和嗜碱性粒细胞/淋巴细胞比率（BLR）。此外,我们获得了SII和单核细胞/HDL率。
结果：患者白细胞（p<0.001），血小板（p<0.001），plateletcrit（PCT）（p=0.002），中性粒细胞（p<0.001），单核细胞（p=0.002），CRP（p<0.001），NLR（p=0.001），PLR（p=0.004），MLR（p=0.009），SII（p<0.001）和单核细胞/HDL比率（p<0.001）均高于对照组。我们观察到每天的甲基苯丙胺摄入量之间存在显着的正相关关系，和甲基苯丙胺的使用持续时间（p=0.002），PCT（p=0.044），中性粒细胞（p=0.021），NLR（p=0.001），PLR（p=0.004），MLR（p=0.029），和SII(p<0.001)。每日甲基苯丙胺摄入量对SII有显著的积极影响。每天甲基苯丙胺摄入量增加一个单位，SII就会增加165.53个单位。
结论：结果证实在MUD成年男性患者中存在外周亚临床炎症和全身免疫炎症。
