Abstract：
Licochalcone A (LCA) is extracted from licorice plants and used as a food additive. Citric acid (CA) and alanine (Ala) are food additives with good regulatory functions. This study aims to investigate the formation and in vitro release mechanism of the LCA eutectogel using supramolecular self-assembly technology. The mechanism of self-assembly indicates that the resulting eutectogel has strong intermolecular interactions. The formation mechanism of LCA eutectogel suggests that LCA is dispersed in nano form in the DES solution before self-assembly and dispersed in molecular form in the eutectogel after self-assembly. Mesoscopic MD simulation studies indicate that the interaction energy between LCA Ala-CA(5:5) eutectogel and the solvent interface is relatively low, suggesting it may have a better drug release rate, consistent with the in vitro release results. In conclusion, the study successfully prepares LCA eutectogel and provides theoretical guidance for the development and application of novel eutectogel for food application.
摘要：
LicochalconeA（LCA）从甘草植物中提取并用作食品添加剂。柠檬酸(CA)和丙氨酸(Ala)是具有良好调节功能的食品添加剂。本研究旨在利用超分子自组装技术研究LCA共晶的形成和体外释放机制。自组装的机制表明，所得共晶具有很强的分子间相互作用。LCA共晶的形成机理表明，LCA在自组装前以纳米形式分散在DES溶液中，在自组装后以分子形式分散在共晶中。介观MD模拟研究表明，LCAAla-CA(5:5)共晶与溶剂界面的相互作用能相对较低，表明它可能有更好的药物释放速率，与体外释放结果一致。总之,本研究成功制备了LCA共晶合金，为新型食品共晶合金的开发和应用提供了理论指导。
