METHODS: The study was carried out by obtaining the data of PBSC mobilizations performed between January 2009 and September 2022 in our transplantation center.
RESULTS: A total of 141 healthy donors with a median donor age of 32 (18-64) were included. Adequate mobilization was achieved in 115 (81.6 %) patients. Median peripheral CD34 + cell count was 69.4/μL in the adequate mobilization group and 46/μL in the mobilization failure group (p < 0001). Multivariate analysis revealed that donor/recipient weight ratio and the 4th day peripheral CD34 + cell count≥ 50/μL were independent markers for 4th day collection success. A predictive model of our center including these parameters was available with 0.765 sensitivity and 0.968 specificity [(AUC):0.948 (95 % CI, 0.90-0.99), p < 0.001].
CONCLUSIONS: The result of the current study shows that peripheral 4th day collection can be performed in selected donors, taking into account peripheral CD34+ cell count and donor/recipient weight ratio. In addition, using these indicators, new predictive models can be created that may assist clinicians in daily practice.
方法:该研究是通过获取2009年1月至2022年9月在我们的移植中心进行的PBSC动员的数据进行的。
结果:共纳入141名健康供体,供体年龄中位数为32岁(18-64岁)。115例(81.6%)患者实现了足够的动员。在充分动员组中,外周CD34+细胞计数中位数为69.4/μL,在动员失败组中为46/μL(p<0001)。多变量分析显示,供体/受体体重比和第4天外周血CD34细胞计数≥50/μL是第4天收集成功的独立标志物。我们中心的预测模型包括这些参数,具有0.765的灵敏度和0.968的特异性[(AUC):0.948(95%CI,0.90-0.99),p<0.001]。
结论:当前研究的结果表明,可以在选定的供体中进行第4天的外周采集,考虑到外周CD34+细胞计数和供体/受体体重比。此外,使用这些指标,可以创建新的预测模型,以帮助临床医生进行日常实践。