PDF(Pubmed)
Abstract：
OBJECTIVE: Current evidence supports the benefits of cochlear implants (CIs) in children with hearing loss, including those with auditory neuropathy spectrum disorder (ANSD). However, there is limited evidence regarding factors that hold predictive value for intervention outcomes.
METHODS: This retrospective case-control study consisted of 66 children with CIs, including 22 with ANSD and 44 with sensorineural hearing loss (SNHL) matched on sex, age, age at CI activation, and the length of follow-up with CIs (1:2 ratio). The case and control groups were compared in the results of five open-set speech perception tests, and a Forward Linear Regression Model was used to identify factors that can predict the post-CI outcomes.
RESULTS: There was no significant difference in average scores between the two groups across five outcome measures, ranging from 88.40% to 95.65%. The correlation matrix revealed that younger ages at hearing aid fitting and CI activation positively influenced improvements in speech perception test scores. Furthermore, among the variables incorporated in the regression model, the duration of follow-up with CIs, age at CI activation, and the utilization of two CIs demonstrated prognostic significance for improved post-CI speech perception outcomes.
CONCLUSIONS: Children with ANSD can achieve similar open-set speech perception outcomes as children with SNHL. A longer CI follow-up, a lower age at CI activation, and the use of two CIs are predictive for optimal CI outcome.
METHODS: This retrospective case-control study consisted of 66 children with CIs, including 22 with ANSD and 44 with sensorineural hearing loss (SNHL) matched on sex, age, age at CI activation, and the length of follow-up with CIs (1:2 ratio). The case and control groups were compared in the results of five open-set speech perception tests, and a Forward Linear Regression Model was used to identify factors that can predict the post-CI outcomes.
RESULTS: There was no significant difference in average scores between the two groups across five outcome measures, ranging from 88.40% to 95.65%. The correlation matrix revealed that younger ages at hearing aid fitting and CI activation positively influenced improvements in speech perception test scores. Furthermore, among the variables incorporated in the regression model, the duration of follow-up with CIs, age at CI activation, and the utilization of two CIs demonstrated prognostic significance for improved post-CI speech perception outcomes.
CONCLUSIONS: Children with ANSD can achieve similar open-set speech perception outcomes as children with SNHL. A longer CI follow-up, a lower age at CI activation, and the use of two CIs are predictive for optimal CI outcome.
摘要：
目的：目前的证据支持人工耳蜗植入对听力损失儿童的益处，包括听觉神经病变谱系障碍（ANSD）。然而,关于对干预结局具有预测价值的因素的证据有限.
方法：这项回顾性病例对照研究包括66例CI患儿，包括22名ANSD患者和44名性别匹配的感音神经性听力损失（SNHL）患者，年龄,年龄atCI激活，和随访时间的CIs（1：2比率）。病例组和对照组在五个开放式言语感知测试的结果中进行比较,并使用正向线性回归模型来确定可以预测CI后结果的因素。
结果：在5项结果指标中，两组的平均得分没有显著差异，从88.40%到95.65%不等。相关矩阵显示，助听器安装和CI激活的年龄较小，对言语感知测试分数的改善有积极影响。此外，在回归模型中包含的变量中，CI的随访持续时间，年龄atCI激活，两种CI的利用证明了改善CI后言语感知结果的预后意义。
结论：患有ANSD的儿童可以获得与SNHL儿童相似的开放式言语感知结果。长期CI随访，较低年龄的atCI激活，并且使用两个CI可以预测最佳CI结果。
方法：这项回顾性病例对照研究包括66例CI患儿，包括22名ANSD患者和44名性别匹配的感音神经性听力损失（SNHL）患者，年龄,年龄atCI激活，和随访时间的CIs（1：2比率）。病例组和对照组在五个开放式言语感知测试的结果中进行比较,并使用正向线性回归模型来确定可以预测CI后结果的因素。
结果：在5项结果指标中，两组的平均得分没有显著差异，从88.40%到95.65%不等。相关矩阵显示，助听器安装和CI激活的年龄较小，对言语感知测试分数的改善有积极影响。此外，在回归模型中包含的变量中，CI的随访持续时间，年龄atCI激活，两种CI的利用证明了改善CI后言语感知结果的预后意义。
结论：患有ANSD的儿童可以获得与SNHL儿童相似的开放式言语感知结果。长期CI随访，较低年龄的atCI激活，并且使用两个CI可以预测最佳CI结果。
