Abstract：
OBJECTIVE: This study aims to evaluate the validity and reliability of tubomanometry (TMM) in diagnosing obstructive Eustachian tube dysfunction (OETD) before balloon Eustachian tuboplasty (BET).
METHODS: A prospective cohort study was conducted, involving 25 patients with sinonasal pathology, 75 patients with middle ear disease, and 25 healthy subjects, totaling 250 ears. All participants underwent comprehensive physical examinations, including TMM, nasal videoendoscopy, otoendoscopy, Valsalva maneuver (VM), tympanometry, and audiometry. Additionally, various scales such as ETDQ-7 and ETS-7 were employed. Tympanometry served as the gold standard for assessing OETD, and comparisons were made among the measures across the three groups.
RESULTS: Among the 125 participants, 44.8% (n = 56) were female, and 55.2% (n = 69) were male, with ages ranging from 19 to 93 years (M = 48.5; SD = 15.6). In our study, VM demonstrated high sensitivity (86.3%) when tympanometry was considered the gold standard. Conversely, TMM, ETDQ-7, and ETS-7 exhibited high specificity, with ETDQ-7 showing the highest specificity (87.4%). Regarding TMM, all R values in patients within the middle ear disease group were pathological (R > 1).
CONCLUSIONS: TMM has exhibited notable specificity as a diagnostic tool compared to tympanogram and VM. Nonetheless, the combination of TMM and ETDQ-7 has enabled us to conduct a diagnostic assessment with high sensitivity and specificity for chronic OETD diagnosis.
METHODS: A prospective cohort study was conducted, involving 25 patients with sinonasal pathology, 75 patients with middle ear disease, and 25 healthy subjects, totaling 250 ears. All participants underwent comprehensive physical examinations, including TMM, nasal videoendoscopy, otoendoscopy, Valsalva maneuver (VM), tympanometry, and audiometry. Additionally, various scales such as ETDQ-7 and ETS-7 were employed. Tympanometry served as the gold standard for assessing OETD, and comparisons were made among the measures across the three groups.
RESULTS: Among the 125 participants, 44.8% (n = 56) were female, and 55.2% (n = 69) were male, with ages ranging from 19 to 93 years (M = 48.5; SD = 15.6). In our study, VM demonstrated high sensitivity (86.3%) when tympanometry was considered the gold standard. Conversely, TMM, ETDQ-7, and ETS-7 exhibited high specificity, with ETDQ-7 showing the highest specificity (87.4%). Regarding TMM, all R values in patients within the middle ear disease group were pathological (R > 1).
CONCLUSIONS: TMM has exhibited notable specificity as a diagnostic tool compared to tympanogram and VM. Nonetheless, the combination of TMM and ETDQ-7 has enabled us to conduct a diagnostic assessment with high sensitivity and specificity for chronic OETD diagnosis.
摘要：
目的：本研究旨在评估球囊咽鼓管成形术（BET）前，管测法（TMM）诊断阻塞性咽鼓管功能障碍（OETD）的有效性和可靠性。
方法：进行了前瞻性队列研究，涉及25例鼻窦病理患者，75例中耳疾病患者，和25个健康的受试者，250只耳朵所有参与者都接受了全面的体检，包括TMM,鼻内窥镜检查,耳内镜检查,Valsalva机动（VM），鼓室测压,和测听法。此外,采用了各种量表，如ETDQ-7和ETS-7。鼓室测量法是评估OETD的黄金标准，并对三组的测量结果进行了比较。
结果：在125名参与者中，44.8%(n=56)为女性，55.2%(n=69)为男性，年龄为19至93岁（M=48.5；SD=15.6）。在我们的研究中,当鼓室测压被认为是金标准时，VM表现出高灵敏度(86.3%)。相反，TMM,ETDQ-7和ETS-7表现出高特异性，ETDQ-7表现出最高的特异性（87.4%）。关于TMM,中耳疾病组患者的所有R值均为病理性(R>1)。
结论：与鼓室图和VM相比，TMM作为诊断工具表现出显著的特异性。尽管如此，TMM和ETDQ-7的结合使我们能够对慢性OETD诊断进行高灵敏度和特异性的诊断评估.
方法：进行了前瞻性队列研究，涉及25例鼻窦病理患者，75例中耳疾病患者，和25个健康的受试者，250只耳朵所有参与者都接受了全面的体检，包括TMM,鼻内窥镜检查,耳内镜检查,Valsalva机动（VM），鼓室测压,和测听法。此外,采用了各种量表，如ETDQ-7和ETS-7。鼓室测量法是评估OETD的黄金标准，并对三组的测量结果进行了比较。
结果：在125名参与者中，44.8%(n=56)为女性，55.2%(n=69)为男性，年龄为19至93岁（M=48.5；SD=15.6）。在我们的研究中,当鼓室测压被认为是金标准时，VM表现出高灵敏度(86.3%)。相反，TMM,ETDQ-7和ETS-7表现出高特异性，ETDQ-7表现出最高的特异性（87.4%）。关于TMM,中耳疾病组患者的所有R值均为病理性(R>1)。
结论：与鼓室图和VM相比，TMM作为诊断工具表现出显著的特异性。尽管如此，TMM和ETDQ-7的结合使我们能够对慢性OETD诊断进行高灵敏度和特异性的诊断评估.
