Abstract：
BACKGROUND: Chemical exfoliation of the skin is a frequently utilized treatment in dermatology to improve the appearance and health of photoaged skin. Photodamaged skin is especially prone to dryness and irritation. Over-exfoliation with at-home products are partially to blame for the \"epidemic\" of sensitive skin affecting over half the population. Combining AHA, BHA, and PHA together creates a complementary blend that has the potential to target numerous age-related changes in the skin including the appearance of pores and smoothing skin texture, while firming skin and increasing its collagen and moisture content.
OBJECTIVE: The following study tested the clinical efficacy of a triple acid blend designed specifically for sensitive skin and measured improvements in signs of photodamage and hydration levels in the skin over time.
METHODS: Thirty females aged 35-60 with mild to moderate facial lines, wrinkles, sun damage, uneven skin tone/texture, dark spots, or pores were enrolled. Subjects were instructed to use the test article, DWB-EN, on a clean face at night 3 times weekly with 48 h between applications for 4 weeks.
RESULTS: Statistically significant improvements were noted in all parameters of photoaging clinical assessments (wrinkles, pores, overall appearance, luminosity, visible texture, skin tone evenness, hyperpigmentation) at the end of the 4-week study period. There were no instances of skin irritation throughout the duration of this study despite half of the women having sensitive skin.
CONCLUSIONS: Overall, this study demonstrated the clinical efficacy and tolerability of DWB-EN for treating photoaging in subjects with all skin types.
OBJECTIVE: The following study tested the clinical efficacy of a triple acid blend designed specifically for sensitive skin and measured improvements in signs of photodamage and hydration levels in the skin over time.
METHODS: Thirty females aged 35-60 with mild to moderate facial lines, wrinkles, sun damage, uneven skin tone/texture, dark spots, or pores were enrolled. Subjects were instructed to use the test article, DWB-EN, on a clean face at night 3 times weekly with 48 h between applications for 4 weeks.
RESULTS: Statistically significant improvements were noted in all parameters of photoaging clinical assessments (wrinkles, pores, overall appearance, luminosity, visible texture, skin tone evenness, hyperpigmentation) at the end of the 4-week study period. There were no instances of skin irritation throughout the duration of this study despite half of the women having sensitive skin.
CONCLUSIONS: Overall, this study demonstrated the clinical efficacy and tolerability of DWB-EN for treating photoaging in subjects with all skin types.
摘要：
背景:皮肤的化学去角质是皮肤病学中经常使用的治疗方法,以改善光老化皮肤的外观和健康。光损伤的皮肤特别容易干燥和刺激。家庭产品的过度去角质部分归咎于敏感皮肤的“流行病”，影响了超过一半的人口。结合AHA，BHA,和PHA共同创造了一种互补的混合物，有可能针对许多与年龄相关的皮肤变化，包括毛孔的外观和平滑的皮肤纹理，同时紧致皮肤并增加其胶原蛋白和水分含量。
目的：以下研究测试了专门为敏感皮肤设计的三酸混合物的临床功效，并测量了皮肤中光损伤迹象和水合水平随时间的改善。
方法：30名35-60岁女性，面部有轻度至中度线条，皱纹,阳光伤害,肤色/纹理不均匀，黑点,或毛孔登记。受试者被指示使用测试物品，DWB-EN,晚上在干净的脸上，每周3次，间隔48小时，持续4周。
结果：在光老化临床评估的所有参数（皱纹，毛孔,整体外观,光度,可见纹理,肤色均匀度，色素沉着过度）在4周研究期结束时。尽管一半的女性具有敏感皮肤,但在整个研究期间没有皮肤刺激的情况。
结论：总体而言，这项研究证明了DWB-EN治疗所有皮肤类型受试者光老化的临床疗效和耐受性.
目的：以下研究测试了专门为敏感皮肤设计的三酸混合物的临床功效，并测量了皮肤中光损伤迹象和水合水平随时间的改善。
方法：30名35-60岁女性，面部有轻度至中度线条，皱纹,阳光伤害,肤色/纹理不均匀，黑点,或毛孔登记。受试者被指示使用测试物品，DWB-EN,晚上在干净的脸上，每周3次，间隔48小时，持续4周。
结果：在光老化临床评估的所有参数（皱纹，毛孔,整体外观,光度,可见纹理,肤色均匀度，色素沉着过度）在4周研究期结束时。尽管一半的女性具有敏感皮肤,但在整个研究期间没有皮肤刺激的情况。
结论：总体而言，这项研究证明了DWB-EN治疗所有皮肤类型受试者光老化的临床疗效和耐受性.
