PDF(Pubmed)
Abstract：
BACKGROUND: Severe acne breakouts often lead to atrophic acne scars, which affect millions of people worldwide and can significantly affect a person\'s self-confidence and self-image. Given the difficulty in treating atrophic acne scars, this study aims to investigate the efficacy of topical phenytoin in the treatment of atrophic acne scars.
METHODS: This split face clinical trial on 25 patients between the ages of 18 and 40 involved the application of microneedling on one side of the face, with three sessions taking place over the course of a month. On the other side, a 1% phenytoin cream was administered three times daily for 1 week following the microneedling procedure. Baseline information was collected for all patients, and follow-up assessments were conducted during the treatment sessions and 2 months after the last session. The assessments included evaluating the number and area of pores and spots, determining scar severity, assessing patient satisfaction, and recording any potential complications.
RESULTS: Among patients, 20 individuals (80%) were females, and the average age of the participants was 35.96 ± 9.23. In terms of the fine pore area, despite the fine pore count, both groups showed improvement over time (p: 0.03 vs. 0.06). Also, regarding large pore count and area, and the count and area of spots, both groups showed improvement over time (p: 0.001). However, there were no significant differences between the two groups (p > 0.05). On the other hand, when it comes to acne scar grade and patients\' satisfaction, the phenytoin group outperformed the control group in all follow-up sessions and this difference was found to be significant (p: 0.001). It is worth noting that no complications were observed among any of the patients.
CONCLUSIONS: It appears that combining phenytoin cream with microneedling has a more effective therapeutic outcome in enhancing atrophic acne scars, when compared to microneedling alone, and this method can be regarded as a viable alternative in treating these types of scars.
METHODS: This split face clinical trial on 25 patients between the ages of 18 and 40 involved the application of microneedling on one side of the face, with three sessions taking place over the course of a month. On the other side, a 1% phenytoin cream was administered three times daily for 1 week following the microneedling procedure. Baseline information was collected for all patients, and follow-up assessments were conducted during the treatment sessions and 2 months after the last session. The assessments included evaluating the number and area of pores and spots, determining scar severity, assessing patient satisfaction, and recording any potential complications.
RESULTS: Among patients, 20 individuals (80%) were females, and the average age of the participants was 35.96 ± 9.23. In terms of the fine pore area, despite the fine pore count, both groups showed improvement over time (p: 0.03 vs. 0.06). Also, regarding large pore count and area, and the count and area of spots, both groups showed improvement over time (p: 0.001). However, there were no significant differences between the two groups (p > 0.05). On the other hand, when it comes to acne scar grade and patients\' satisfaction, the phenytoin group outperformed the control group in all follow-up sessions and this difference was found to be significant (p: 0.001). It is worth noting that no complications were observed among any of the patients.
CONCLUSIONS: It appears that combining phenytoin cream with microneedling has a more effective therapeutic outcome in enhancing atrophic acne scars, when compared to microneedling alone, and this method can be regarded as a viable alternative in treating these types of scars.
摘要：
背景：严重的痤疮爆发通常会导致萎缩性痤疮疤痕，这影响着全世界数百万人，并能显著影响一个人的自信和自我形象。鉴于治疗萎缩性痤疮疤痕的困难，本研究旨在探讨外用苯妥英治疗萎缩性痤疮瘢痕的疗效。
方法：这项针对25名年龄在18至40岁之间的患者的面部分裂临床试验涉及在面部一侧应用微针，在一个月的时间里举行了三次会议。在另一边,1％苯妥英乳膏每日三次，持续1周。收集所有患者的基线信息，在治疗期间和最后一次治疗后2个月进行随访评估.评估包括评估毛孔和斑点的数量和面积，确定疤痕严重程度，评估患者满意度，并记录任何潜在的并发症。
结果：在患者中，20个人（80％）是女性，参与者的平均年龄为35.96±9.23。在细孔面积方面，尽管细毛孔计数，两组都显示出随着时间的推移而改善(p:0.03vs.0.06)。此外，关于大孔隙数和面积，斑点的数量和面积，两组均显示随时间改善(p:0.001).然而,两组间差异无统计学意义(p>0.05)。另一方面,当谈到痤疮疤痕等级和患者满意度时，苯妥英组在所有随访中的表现均优于对照组,并且发现这一差异是显著的(p:0.001).值得注意的是，在任何患者中都没有观察到并发症。
结论：看来，将苯妥英乳膏与微针结合使用在改善萎缩性痤疮疤痕方面具有更有效的治疗效果，与单独的微针相比，这种方法可以被认为是治疗这些类型疤痕的可行替代方法。
方法：这项针对25名年龄在18至40岁之间的患者的面部分裂临床试验涉及在面部一侧应用微针，在一个月的时间里举行了三次会议。在另一边,1％苯妥英乳膏每日三次，持续1周。收集所有患者的基线信息，在治疗期间和最后一次治疗后2个月进行随访评估.评估包括评估毛孔和斑点的数量和面积，确定疤痕严重程度，评估患者满意度，并记录任何潜在的并发症。
结果：在患者中，20个人（80％）是女性，参与者的平均年龄为35.96±9.23。在细孔面积方面，尽管细毛孔计数，两组都显示出随着时间的推移而改善(p:0.03vs.0.06)。此外，关于大孔隙数和面积，斑点的数量和面积，两组均显示随时间改善(p:0.001).然而,两组间差异无统计学意义(p>0.05)。另一方面,当谈到痤疮疤痕等级和患者满意度时，苯妥英组在所有随访中的表现均优于对照组,并且发现这一差异是显著的(p:0.001).值得注意的是，在任何患者中都没有观察到并发症。
结论：看来，将苯妥英乳膏与微针结合使用在改善萎缩性痤疮疤痕方面具有更有效的治疗效果，与单独的微针相比，这种方法可以被认为是治疗这些类型疤痕的可行替代方法。
