Abstract：
SOCS (Suppressor of Cytokine Signalling) proteins are intracellular negative regulators that primarily modulate and inhibit cytokine-mediated signal transduction, playing a crucial role in immune homeostasis and related inflammatory diseases. SOCS act as inhibitors by regulating the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway, thereby intervening in the pathogenesis of inflammation and autoimmune diseases. Recent studies have also demonstrated their involvement in central immunity and neuroinflammation, showing a dual functionality. However, the specific mechanisms of SOCS in the central nervous system remain unclear. This review thoroughly elucidates the specific mechanisms linking the SOCS-JAK-STAT pathway with the inflammatory manifestations of neurodegenerative diseases. Based on this, it proposes the theory that SOCS proteins can regulate the JAK-STAT pathway and inhibit the occurrence of neuroinflammation. Additionally, this review explores in detail the current therapeutic landscape and potential of targeting SOCS in the brain via the JAK-STAT pathway for neuroinflammation, offering insights into potential targets for the treatment of neurodegenerative diseases.
摘要：
SOCS（细胞因子信号抑制）蛋白是细胞内负调节因子，主要调节和抑制细胞因子介导的信号转导，在免疫稳态和相关炎性疾病中起着至关重要的作用。SOCS通过调节Janus激酶-信号转导子和转录激活因子（JAK-STAT）信号通路作为抑制剂，从而干预炎症和自身免疫性疾病的发病机理。最近的研究还表明，它们参与中枢免疫和神经炎症，显示双重功能。然而,SOCS在中枢神经系统中的具体机制尚不清楚。这篇综述彻底阐明了将SOCS-JAK-STAT通路与神经退行性疾病的炎症表现联系起来的具体机制。基于此,提出了SOCS蛋白可以调节JAK-STAT通路，抑制神经炎症的发生的理论。此外,这篇综述详细探讨了当前的治疗前景和通过JAK-STAT通路靶向神经炎症的大脑中的SOCS的潜力，提供对神经退行性疾病治疗的潜在靶点的见解。
