PDF(Pubmed)
Abstract：
Gregor Mendel developed the principles of segregation and independent assortment in the mid-1800s based on his detailed analysis of several traits in pea plants. Those principles, now called Mendel\'s laws, in fact, explain the behavior of genes and alleles during meiosis and are now understood to underlie \"Mendelian inheritance\" of a wide range of traits and diseases across organisms. When asked to give examples of inheritance that do NOT follow Mendel\'s laws, in other words, examples of non-Mendelian inheritance, students sometimes list incomplete dominance, codominance, multiple alleles, sex-linked traits, and multigene traits and cite as their sources the Khan Academy, Wikipedia, and other online sites. Against this background, the goals of this Perspective are to (1) explain to students, healthcare workers, and other stakeholders why the examples above, in fact, display Mendelian inheritance, as they obey Mendel\'s laws of segregation and independent assortment, even though they do not produce classic Mendelian phenotypic ratios and (2) urge individuals with an intimate knowledge of genetic principles to monitor the accuracy of learning resources and work with us and those resources to correct information that is misleading.
摘要：
孟德尔在1800年代中期根据他对豌豆植物的几个性状的详细分析，发展了分离和独立分类的原则。这些原则,现在被称为孟德尔定律，事实上,解释减数分裂过程中基因和等位基因的行为，现在被认为是生物体内各种性状和疾病的“孟德尔遗传”的基础。当被要求给出不遵循孟德尔定律的继承例子时，换句话说,非孟德尔继承的例子，学生有时会列出不完整的优势，共优势,多个等位基因，与性别相关的特征，和多基因特征，并引用可汗学院作为它们的来源，维基百科,和其他在线网站。在这种背景下,这个观点的目标是(1)向学生解释，医护人员,和其他利益相关者为什么上面的例子，事实上,显示孟德尔继承，因为他们遵守孟德尔的种族隔离和独立分类的法律，即使它们不产生经典的孟德尔表型比率，并且（2）敦促对遗传原理有深入了解的个人监控学习资源的准确性，并与我们和这些资源合作以纠正误导性信息。
