Abstract：
OBJECTIVE: Accurate prediction of preeclampsia could improve maternal outcomes. However, the role of uterine artery Doppler ultrasound in predicting preeclampsia remains unclear.
METHODS: We comprehensively searched several electronic databases, including PubMed, EMBASE, the Cochrane Library, and Web of Science, covering studies published from the time of database creation to September 23, 2023. Studies on the predictive value of uterine artery Doppler ultrasound for preeclampsia were included. The primary pregnancy outcome was preeclampsia. The risk of bias was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 scoring scale.
RESULTS: The use of resistance index (RI) for predicting preeclampsia demonstrated the highest sensitivity of 0.73 (95% confidence interval [CI], 0.30-0.94) and specificity of 0.90 (95% CI, 0.72-0.97), with a pooled area under the curve value of 0.91 (95% CI, 0.88-0.93). The use of pulsatility index (PI) for predicting preeclampsia showed a sensitivity of 0.65 (95% CI, 0.45-0.81) and specificity of 0.88 (95% CI, 0.77-0.94). Furthermore, preeclampsia prediction via notching showed a sensitivity of 0.54 (95% CI, 0.38-0.68) and specificity of 0.89 (95% CI, 0.79-0.95).
CONCLUSIONS: These findings highlight the varying predictive performance of different preeclampsia indices. PI and RI demonstrated moderate-to-high sensitivity and specificity, whereas notching exhibited relatively lower sensitivity but comparable specificity. Further research and validation are warranted to consolidate these results and enhance the accuracy of preeclampsia prediction.
METHODS: We comprehensively searched several electronic databases, including PubMed, EMBASE, the Cochrane Library, and Web of Science, covering studies published from the time of database creation to September 23, 2023. Studies on the predictive value of uterine artery Doppler ultrasound for preeclampsia were included. The primary pregnancy outcome was preeclampsia. The risk of bias was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 scoring scale.
RESULTS: The use of resistance index (RI) for predicting preeclampsia demonstrated the highest sensitivity of 0.73 (95% confidence interval [CI], 0.30-0.94) and specificity of 0.90 (95% CI, 0.72-0.97), with a pooled area under the curve value of 0.91 (95% CI, 0.88-0.93). The use of pulsatility index (PI) for predicting preeclampsia showed a sensitivity of 0.65 (95% CI, 0.45-0.81) and specificity of 0.88 (95% CI, 0.77-0.94). Furthermore, preeclampsia prediction via notching showed a sensitivity of 0.54 (95% CI, 0.38-0.68) and specificity of 0.89 (95% CI, 0.79-0.95).
CONCLUSIONS: These findings highlight the varying predictive performance of different preeclampsia indices. PI and RI demonstrated moderate-to-high sensitivity and specificity, whereas notching exhibited relatively lower sensitivity but comparable specificity. Further research and validation are warranted to consolidate these results and enhance the accuracy of preeclampsia prediction.
摘要：
目的：准确预测子痫前期可以改善产妇结局。然而,子宫动脉多普勒超声在预测子痫前期中的作用尚不清楚.
方法：我们全面搜索了几个电子数据库，包括PubMed,EMBASE,Cochrane图书馆,和WebofScience,涵盖从数据库创建到2023年9月23日发表的研究。研究子宫动脉多普勒超声对子痫前期的预测价值。主要妊娠结局为先兆子痫。使用诊断准确性研究质量评估-2评分量表评估偏倚风险。
结果：使用抵抗指数（RI）预测先兆子痫的敏感性最高，为0.73（95％置信区间[CI]，0.30-0.94)和特异性为0.90(95%CI，0.72-0.97)，合并的曲线下面积值为0.91（95%CI，0.88-0.93）。使用搏动指数（PI）预测先兆子痫的敏感性为0.65（95％CI，0.45-0.81），特异性为0.88（95％CI，0.77-0.94）。此外，通过切口预测先兆子痫的敏感性为0.54(95%CI,0.38-0.68),特异性为0.89(95%CI,0.79-0.95).
结论：这些发现突出了不同先兆子痫指数的不同预测性能。PI和RI表现出中至高的敏感性和特异性，而缺口显示出相对较低的敏感性，但特异性相当。需要进一步的研究和验证来巩固这些结果并提高先兆子痫预测的准确性。
方法：我们全面搜索了几个电子数据库，包括PubMed,EMBASE,Cochrane图书馆,和WebofScience,涵盖从数据库创建到2023年9月23日发表的研究。研究子宫动脉多普勒超声对子痫前期的预测价值。主要妊娠结局为先兆子痫。使用诊断准确性研究质量评估-2评分量表评估偏倚风险。
结果：使用抵抗指数（RI）预测先兆子痫的敏感性最高，为0.73（95％置信区间[CI]，0.30-0.94)和特异性为0.90(95%CI，0.72-0.97)，合并的曲线下面积值为0.91（95%CI，0.88-0.93）。使用搏动指数（PI）预测先兆子痫的敏感性为0.65（95％CI，0.45-0.81），特异性为0.88（95％CI，0.77-0.94）。此外，通过切口预测先兆子痫的敏感性为0.54(95%CI,0.38-0.68),特异性为0.89(95%CI,0.79-0.95).
结论：这些发现突出了不同先兆子痫指数的不同预测性能。PI和RI表现出中至高的敏感性和特异性，而缺口显示出相对较低的敏感性，但特异性相当。需要进一步的研究和验证来巩固这些结果并提高先兆子痫预测的准确性。
