METHODS: This study included consecutive patients who underwent balloon angioplasty from December 2016 to October 2020. AccuFFRangio was calculated retrospectively based on the post-procedural angiography obtained immediately after angioplasty. The primary endpoint was major adverse cardiac events (MACE), defined as a composite of all-cause death, vessel-related myocardial infarction, and repeat target vessel revascularization.
RESULTS: A total of 169 patients were retrospectively analyzed in this study. Post-procedural AccuFFRangio (hazard ratio [HR] per 0.1 increase 0.33, 95% confidence interval [CI] 0.22-0.48, p < 0.001) was an independent predictor for MACE at 2-year follow-up. Post-procedural AccuFFRangio ≤ 0.87 was determined as the optimal cutoff value to predict MACE with an area under the curve (AUC) of 0.872 (95% CI 0.813-0.919, p < 0.001).
CONCLUSIONS: AccuFFRangio measured immediately after balloon angioplasty is a promising predictor of unfavorable clinical outcomes.
方法:本研究纳入2016年12月至2020年10月连续接受球囊血管成形术的患者。AccuFFRangio是根据血管成形术后立即获得的术后血管造影进行回顾性计算的。主要终点是主要不良心脏事件(MACE),定义为全因死亡的复合物,血管相关性心肌梗死,并重复目标血管血运重建。
结果:本研究共对169例患者进行了回顾性分析。术后AccuFFRangio(风险比[HR]每0.1增加0.33,95%置信区间[CI]0.22-0.48,p<0.001)是2年随访时MACE的独立预测因子。术后AccuFFRangio≤0.87被确定为预测MACE的最佳临界值,曲线下面积(AUC)为0.872(95%CI0.813-0.919,p<0.001)。
结论:球囊血管成形术后立即测量的AccuFFRangio是不良临床结局的有希望的预测指标。