Abstract：
BACKGROUND: AccuFFRangio is a novel method for fast computation of fractional flow reserve (FFR) based on coronary angiography and computational fluid dynamics. The association between the AccuFFRangio and clinical outcomes after drug-coated balloon (DCB) or plain old balloon angioplasty (POBA) remains to be investigated.
METHODS: This study included consecutive patients who underwent balloon angioplasty from December 2016 to October 2020. AccuFFRangio was calculated retrospectively based on the post-procedural angiography obtained immediately after angioplasty. The primary endpoint was major adverse cardiac events (MACE), defined as a composite of all-cause death, vessel-related myocardial infarction, and repeat target vessel revascularization.
RESULTS: A total of 169 patients were retrospectively analyzed in this study. Post-procedural AccuFFRangio (hazard ratio [HR] per 0.1 increase 0.33, 95% confidence interval [CI] 0.22-0.48, p < 0.001) was an independent predictor for MACE at 2-year follow-up. Post-procedural AccuFFRangio ≤ 0.87 was determined as the optimal cutoff value to predict MACE with an area under the curve (AUC) of 0.872 (95% CI 0.813-0.919, p < 0.001).
CONCLUSIONS: AccuFFRangio measured immediately after balloon angioplasty is a promising predictor of unfavorable clinical outcomes.
METHODS: This study included consecutive patients who underwent balloon angioplasty from December 2016 to October 2020. AccuFFRangio was calculated retrospectively based on the post-procedural angiography obtained immediately after angioplasty. The primary endpoint was major adverse cardiac events (MACE), defined as a composite of all-cause death, vessel-related myocardial infarction, and repeat target vessel revascularization.
RESULTS: A total of 169 patients were retrospectively analyzed in this study. Post-procedural AccuFFRangio (hazard ratio [HR] per 0.1 increase 0.33, 95% confidence interval [CI] 0.22-0.48, p < 0.001) was an independent predictor for MACE at 2-year follow-up. Post-procedural AccuFFRangio ≤ 0.87 was determined as the optimal cutoff value to predict MACE with an area under the curve (AUC) of 0.872 (95% CI 0.813-0.919, p < 0.001).
CONCLUSIONS: AccuFFRangio measured immediately after balloon angioplasty is a promising predictor of unfavorable clinical outcomes.
摘要：
背景：AccuFFRangio是一种基于冠状动脉造影和计算流体动力学的快速计算血流储备分数（FFR）的新颖方法。药物涂层球囊（DCB）或普通旧球囊血管成形术（POBA）后，AccuFFRangio与临床结果之间的关联仍有待研究。
方法：本研究纳入2016年12月至2020年10月连续接受球囊血管成形术的患者。AccuFFRangio是根据血管成形术后立即获得的术后血管造影进行回顾性计算的。主要终点是主要不良心脏事件（MACE），定义为全因死亡的复合物，血管相关性心肌梗死,并重复目标血管血运重建。
结果：本研究共对169例患者进行了回顾性分析。术后AccuFFRangio（风险比[HR]每0.1增加0.33，95％置信区间[CI]0.22-0.48，p<0.001）是2年随访时MACE的独立预测因子。术后AccuFFRangio≤0.87被确定为预测MACE的最佳临界值，曲线下面积（AUC）为0.872（95％CI0.813-0.919，p<0.001）。
结论：球囊血管成形术后立即测量的AccuFFRangio是不良临床结局的有希望的预测指标。
方法：本研究纳入2016年12月至2020年10月连续接受球囊血管成形术的患者。AccuFFRangio是根据血管成形术后立即获得的术后血管造影进行回顾性计算的。主要终点是主要不良心脏事件（MACE），定义为全因死亡的复合物，血管相关性心肌梗死,并重复目标血管血运重建。
结果：本研究共对169例患者进行了回顾性分析。术后AccuFFRangio（风险比[HR]每0.1增加0.33，95％置信区间[CI]0.22-0.48，p<0.001）是2年随访时MACE的独立预测因子。术后AccuFFRangio≤0.87被确定为预测MACE的最佳临界值，曲线下面积（AUC）为0.872（95％CI0.813-0.919，p<0.001）。
结论：球囊血管成形术后立即测量的AccuFFRangio是不良临床结局的有希望的预测指标。
