%0 Journal Article
%T Angiography-based Fractional Flow Reserve for the Prediction of Clinical Outcomes After Drug-coated Balloon or Plain Old Balloon Angioplasty.
%A Wang W
%A Yang X
%A Hu Y
%A Leng X
%A Xiang J
%A Lin X
%J Cardiovasc Drugs Ther
%V 0
%N 0
%D 2024 May 28
%M 38805160
%F 3.947
%R 10.1007/s10557-024-07575-z
%X <B>BACKGROUND: </B>AccuFFRangio is a novel method for fast computation of fractional flow reserve (FFR) based on coronary angiography and computational fluid dynamics. The association between the AccuFFRangio and clinical outcomes after drug-coated balloon (DCB) or plain old balloon angioplasty (POBA) remains to be investigated.<BR><B>METHODS: </B>This study included consecutive patients who underwent balloon angioplasty from December 2016 to October 2020. AccuFFRangio was calculated retrospectively based on the post-procedural angiography obtained immediately after angioplasty. The primary endpoint was major adverse cardiac events (MACE), defined as a composite of all-cause death, vessel-related myocardial infarction, and repeat target vessel revascularization.<BR><B>RESULTS: </B>A total of 169 patients were retrospectively analyzed in this study. Post-procedural AccuFFRangio (hazard ratio [HR] per 0.1 increase 0.33, 95% confidence interval [CI] 0.22-0.48, p < 0.001) was an independent predictor for MACE at 2-year follow-up. Post-procedural AccuFFRangio ≤ 0.87 was determined as the optimal cutoff value to predict MACE with an area under the curve (AUC) of 0.872 (95% CI 0.813-0.919, p < 0.001).<BR><B>CONCLUSIONS: </B>AccuFFRangio measured immediately after balloon angioplasty is a promising predictor of unfavorable clinical outcomes.