Abstract：
UNASSIGNED: The prediction of the individual insulin needs may facilitate the initiation of insulin therapy. Our aim was to explore the relationships between body weight, sex, and daily amounts of insulin delivered by a hybrid closed-loop system.
UNASSIGNED: We performed a retrospective data collection of all consenting adult patients with type 1 diabetes who were equipped in Europe with the Diabeloop Generation 1 (DBLG1) hybrid closed-loop insulin delivery device between March 1, 2021 and February 28, 2023.
UNASSIGNED: A total of 9036 users (59% females, age 45.6 ± 14.3 years) were included, reaching a mean follow-up of 320 ± 143 days, an overall 2 887 188 days of data. We observed a mean insulin-weight ratio of 0.617 ± 0.207 U/kg (0.665 ± 0.217 for males and 0.584 ± 0.193 for females, P < .001). Exploratory analysis of a subset of 4066 patients reaching >70% Time in Range (70-180 mg/dL) showed a mean insulin-weight ratio of 0.55 ± 0.17 U/kg (P < .001) (0.59 ± 0.18 for the 1438 males and 0.53 ± 0.16 for the 2628 females).
UNASSIGNED: This large real-world analysis provides a quantitative estimation of the daily insulin requirements in adult patients with type 1 diabetes and shows significant differences between sex. These findings have relevant implications in the practical management of insulin therapy.
UNASSIGNED: We performed a retrospective data collection of all consenting adult patients with type 1 diabetes who were equipped in Europe with the Diabeloop Generation 1 (DBLG1) hybrid closed-loop insulin delivery device between March 1, 2021 and February 28, 2023.
UNASSIGNED: A total of 9036 users (59% females, age 45.6 ± 14.3 years) were included, reaching a mean follow-up of 320 ± 143 days, an overall 2 887 188 days of data. We observed a mean insulin-weight ratio of 0.617 ± 0.207 U/kg (0.665 ± 0.217 for males and 0.584 ± 0.193 for females, P < .001). Exploratory analysis of a subset of 4066 patients reaching >70% Time in Range (70-180 mg/dL) showed a mean insulin-weight ratio of 0.55 ± 0.17 U/kg (P < .001) (0.59 ± 0.18 for the 1438 males and 0.53 ± 0.16 for the 2628 females).
UNASSIGNED: This large real-world analysis provides a quantitative estimation of the daily insulin requirements in adult patients with type 1 diabetes and shows significant differences between sex. These findings have relevant implications in the practical management of insulin therapy.
摘要：
■对个体胰岛素需求的预测可以促进胰岛素治疗的开始。我们的目的是探索体重之间的关系，性别,以及通过混合闭环系统输送的每日胰岛素量。
■我们对2021年3月1日至2023年2月28日在欧洲配备了DiabeloopGeneration1（DBLG1）混合闭环胰岛素给药装置的所有同意的1型糖尿病成年患者进行了回顾性数据收集。
■共有9036个用户（59%为女性，年龄45.6±14.3岁)包括在内，平均随访320±143天，总共2887188天的数据。我们观察到平均胰岛素体重比为0.617±0.207U/kg（男性为0.665±0.217，女性为0.584±0.193，P<.001)。对4066例患者子集的探索性分析达到70％的时间范围（70-180mg/dL）显示，平均胰岛素重量比为0.55±0.17U/kg（P<.001）（1438名男性为0.59±0.18，2628名女性为0.53±0.16）。
■这项大型现实世界分析提供了对1型糖尿病成年患者每日胰岛素需求量的定量估计，并显示了性别之间的显着差异。这些发现对胰岛素治疗的实际管理具有相关意义。
■我们对2021年3月1日至2023年2月28日在欧洲配备了DiabeloopGeneration1（DBLG1）混合闭环胰岛素给药装置的所有同意的1型糖尿病成年患者进行了回顾性数据收集。
■共有9036个用户（59%为女性，年龄45.6±14.3岁)包括在内，平均随访320±143天，总共2887188天的数据。我们观察到平均胰岛素体重比为0.617±0.207U/kg（男性为0.665±0.217，女性为0.584±0.193，P<.001)。对4066例患者子集的探索性分析达到70％的时间范围（70-180mg/dL）显示，平均胰岛素重量比为0.55±0.17U/kg（P<.001）（1438名男性为0.59±0.18，2628名女性为0.53±0.16）。
■这项大型现实世界分析提供了对1型糖尿病成年患者每日胰岛素需求量的定量估计，并显示了性别之间的显着差异。这些发现对胰岛素治疗的实际管理具有相关意义。
