Abstract：
Plasmid-mediated colistin resistance is an emerging One Health challenge at the human-food-environment interface. In this study, 12 colistin-resistant Escherichia coli carrying mcr-1.1 gene were characterized using whole-genome sequencing. This is the first report from locally produced chicken meat in the United Arab Emirates. The characterized isolates harbored virulence-associated factors ranging from 4 to 17 genes per isolate. The multilocus sequence type 1011 was identified in 5 (41.6%) isolates. Six (50.0%) of the isolates harbored blaCTX-M-55. All of the E. coli isolates contained Incl2 plasmids. This study highlights for the first time chicken meat as a potential reservoir of mcr-1.1 carrying E. coli in the UAE. This study has implications for food safety and underscores the need for comprehensive surveillance strategies to monitor the spread of colistin resistance. Results presented in this short communication address knowledge gaps on the epidemiology of plasmid-mediated colistin resistance in the Middle East food production chain.
摘要：
质粒介导的粘菌素抗性是人类-食物-环境界面上新兴的一种健康挑战。在这项研究中,使用全基因组测序鉴定了12个携带mcr-1.1基因的粘菌素抗性大肠杆菌。这是阿拉伯联合酋长国当地生产的鸡肉的第一份报告。表征的分离株每个分离株具有4至17个基因的毒力相关因子。在5个（41.6％）分离株中鉴定出多位点序列类型1011。六个（50.0％）的分离株携带blaCTX-M-55。所有大肠杆菌分离物含有Incl2质粒。这项研究首次强调鸡肉是阿联酋携带mcr-1.1大肠杆菌的潜在储库。这项研究对食品安全有影响，并强调需要全面的监测策略来监测粘菌素耐药性的传播。此简短通讯中提供的结果解决了中东食品生产链中质粒介导的粘菌素抗性流行病学的知识空白。
