PDF(Pubmed)
Abstract：
UNASSIGNED: 30 male patients with primary inguinal hernias undergoing primary inguinal herniorrhaphy were prospectively recruited for ilioinguinal nerve resection and evaluation. Three samples of the resected ilioinguinal nerve (proximal, canal, and distal) were evaluated using Masson\'s trichrome stain to measure fascicle and total nerve cross-sectional area and detect changes in collagen.
UNASSIGNED: The fascicle cross-sectional area in the canal segment was significantly decreased compared to the proximal control with a large effect size observed (p = 0.016, η2 = 0.16). There was no significant difference in the nerve cross-sectional area between locations, but there was a moderate to large effect size observed between locations (p = 0.165, η2 = 0.105). There was no significant difference in collagen content nor effect size observed between locations (p = 0.99, η2 = 1.503 × 10-4). Interpretation. The decrease in the fascicle cross-sectional area within the inguinal canal further suggests that there is chronic pressure applied by hernia tissue consistent with axon degeneration. Collagen content is uniformly distributed along the length of the nerve. Further studies with larger samples are needed to confirm the observed effect of nerve location on the total nerve cross-sectional area and axon loss.
UNASSIGNED: The fascicle cross-sectional area in the canal segment was significantly decreased compared to the proximal control with a large effect size observed (p = 0.016, η2 = 0.16). There was no significant difference in the nerve cross-sectional area between locations, but there was a moderate to large effect size observed between locations (p = 0.165, η2 = 0.105). There was no significant difference in collagen content nor effect size observed between locations (p = 0.99, η2 = 1.503 × 10-4). Interpretation. The decrease in the fascicle cross-sectional area within the inguinal canal further suggests that there is chronic pressure applied by hernia tissue consistent with axon degeneration. Collagen content is uniformly distributed along the length of the nerve. Further studies with larger samples are needed to confirm the observed effect of nerve location on the total nerve cross-sectional area and axon loss.
摘要：
■前瞻性招募30例男性原发性腹股沟疝患者行原发性腹股沟疝修补术，进行髂腹股沟神经切除和评估。切除的髂腹股沟神经的三个样本（近端，运河,和远端）使用Masson三色染色法进行评估，以测量束和总神经横截面积并检测胶原蛋白的变化。
■与观察到的大效应大小的近端对照相比，管段中的束横截面积显着降低（p=0.016，η2=0.16）。位置之间的神经横截面积没有显着差异，但是在位置之间观察到中等到较大的效应大小（p=0.165，η2=0.105）。位置之间的胶原蛋白含量和效应大小均无显着差异（p=0.99，η2=1.503×10-4）。解释。腹股沟管束横截面积的减小进一步表明，疝组织施加的慢性压力与轴突变性一致。胶原蛋白含量沿着神经的长度均匀分布。需要对更大样本进行进一步研究，以证实观察到的神经位置对总神经横截面积和轴突损失的影响。
■与观察到的大效应大小的近端对照相比，管段中的束横截面积显着降低（p=0.016，η2=0.16）。位置之间的神经横截面积没有显着差异，但是在位置之间观察到中等到较大的效应大小（p=0.165，η2=0.105）。位置之间的胶原蛋白含量和效应大小均无显着差异（p=0.99，η2=1.503×10-4）。解释。腹股沟管束横截面积的减小进一步表明，疝组织施加的慢性压力与轴突变性一致。胶原蛋白含量沿着神经的长度均匀分布。需要对更大样本进行进一步研究，以证实观察到的神经位置对总神经横截面积和轴突损失的影响。
