Abstract：
BACKGROUND: Dementia encompasses a range of neurodegenerative disorders characterized by cognitive decline and functional impairment. The identification of reliable biomarkers is essential for accurate diagnosis and gaining insights into the mechanisms underlying diseases.
OBJECTIVE: This study aimed to investigate the plasma biomarker profiles associated with Brain- Derived Neurotrophic Factor (BDNF), Oxytocin, Neuronal Pentraxin-1 (NPTX1), Triggering Receptor Expressed on Myeloid Cells 2 (TREM2), Tumor Necrosis Factor-alpha (TNF-alpha), Interleukin- 1 (IL-1), and Prolactin in Alzheimer\'s disease (AD), dementia with Lewy bodies (DLB), frontotemporal dementias (FTD), and healthy controls.
METHODS: Serum levels of the aforementioned biomarkers were analyzed in 23 AD, 28 DLB, 15 FTD patients recruited from outpatient units, and 22 healthy controls. Diagnostic evaluations followed established criteria, and standardized clinical tests were conducted. Blood samples were collected and analyzed using ELISA and electrochemiluminescence immunoassay methods.
RESULTS: Serum BDNF and oxytocin levels did not significantly differ across groups. NPTX1, TREM2, TNF-alpha, and IL-1 levels also did not show significant differences among dementia groups. However, prolactin levels exhibited distinct patterns, with lower levels in male DLB patients and higher levels in female AD patients compared to controls.
CONCLUSIONS: The study findings suggest potential shared mechanisms in dementia pathophysiology and highlight the importance of exploring neuroendocrine responses, particularly in AD and DLB. However, further research is warranted to elucidate the role of these biomarkers in dementia diagnosis and disease progression.
OBJECTIVE: This study aimed to investigate the plasma biomarker profiles associated with Brain- Derived Neurotrophic Factor (BDNF), Oxytocin, Neuronal Pentraxin-1 (NPTX1), Triggering Receptor Expressed on Myeloid Cells 2 (TREM2), Tumor Necrosis Factor-alpha (TNF-alpha), Interleukin- 1 (IL-1), and Prolactin in Alzheimer\'s disease (AD), dementia with Lewy bodies (DLB), frontotemporal dementias (FTD), and healthy controls.
METHODS: Serum levels of the aforementioned biomarkers were analyzed in 23 AD, 28 DLB, 15 FTD patients recruited from outpatient units, and 22 healthy controls. Diagnostic evaluations followed established criteria, and standardized clinical tests were conducted. Blood samples were collected and analyzed using ELISA and electrochemiluminescence immunoassay methods.
RESULTS: Serum BDNF and oxytocin levels did not significantly differ across groups. NPTX1, TREM2, TNF-alpha, and IL-1 levels also did not show significant differences among dementia groups. However, prolactin levels exhibited distinct patterns, with lower levels in male DLB patients and higher levels in female AD patients compared to controls.
CONCLUSIONS: The study findings suggest potential shared mechanisms in dementia pathophysiology and highlight the importance of exploring neuroendocrine responses, particularly in AD and DLB. However, further research is warranted to elucidate the role of these biomarkers in dementia diagnosis and disease progression.
摘要：
背景：痴呆包括一系列以认知衰退和功能障碍为特征的神经退行性疾病。识别可靠的生物标志物对于准确诊断和深入了解疾病的潜在机制至关重要。
目的：本研究旨在研究脑源性神经营养因子（BDNF）相关的血浆生物标志物谱，催产素,神经元Pentraxin-1(NPTX1),髓样细胞2（TREM2）上表达的触发受体，肿瘤坏死因子-α(TNF-α),白细胞介素-1(IL-1),和催乳素在阿尔茨海默病（AD）中，路易体痴呆（DLB），额颞叶痴呆（FTD），和健康的控制。
方法：分析了23例AD患者血清中上述生物标志物的水平，28DLB,从门诊单位招募的15名FTD患者，和22个健康对照。诊断评估遵循既定标准，并进行了标准化的临床试验。收集血液样品并使用ELISA和电化学发光免疫测定方法进行分析。
结果：各组血清BDNF和催产素水平无显著差异。NPTX1,TREM2,TNF-α,和IL-1水平在痴呆组之间也没有显着差异。然而,催乳素水平表现出不同的模式，与对照组相比，男性DLB患者的水平较低，女性AD患者的水平较高。
结论：研究发现提示了痴呆病理生理学中潜在的共同机制，并强调了探索神经内分泌反应的重要性。特别是在AD和DLB中。然而,需要进一步的研究来阐明这些生物标志物在痴呆诊断和疾病进展中的作用.
目的：本研究旨在研究脑源性神经营养因子（BDNF）相关的血浆生物标志物谱，催产素,神经元Pentraxin-1(NPTX1),髓样细胞2（TREM2）上表达的触发受体，肿瘤坏死因子-α(TNF-α),白细胞介素-1(IL-1),和催乳素在阿尔茨海默病（AD）中，路易体痴呆（DLB），额颞叶痴呆（FTD），和健康的控制。
方法：分析了23例AD患者血清中上述生物标志物的水平，28DLB,从门诊单位招募的15名FTD患者，和22个健康对照。诊断评估遵循既定标准，并进行了标准化的临床试验。收集血液样品并使用ELISA和电化学发光免疫测定方法进行分析。
结果：各组血清BDNF和催产素水平无显著差异。NPTX1,TREM2,TNF-α,和IL-1水平在痴呆组之间也没有显着差异。然而,催乳素水平表现出不同的模式，与对照组相比，男性DLB患者的水平较低，女性AD患者的水平较高。
结论：研究发现提示了痴呆病理生理学中潜在的共同机制，并强调了探索神经内分泌反应的重要性。特别是在AD和DLB中。然而,需要进一步的研究来阐明这些生物标志物在痴呆诊断和疾病进展中的作用.
