核糖核苷酸还原酶亚基 M2 的抑制增强转移性胰腺神经内分泌肿瘤的放射敏感性。
关键词: Metastases Pancreatic neuroendocrine tumor Radiosensitization Radiotherapy Ribonucleotide reductase inhibitor
Mesh : Humans Pancreatic Neoplasms / pathology radiotherapy genetics drug therapy enzymology Ribonucleoside Diphosphate Reductase / genetics antagonists & inhibitors metabolism Animals Cell Line, Tumor Radiation-Sensitizing Agents / pharmacology Apoptosis / drug effects Cell Proliferation / drug effects Xenograft Model Antitumor Assays Radiation Tolerance / drug effects Mice, Nude Phosphorylation Neuroendocrine Tumors / pathology genetics radiotherapy drug therapy enzymology metabolism Lung Neoplasms / secondary radiotherapy pathology genetics Ataxia Telangiectasia Mutated Proteins / antagonists & inhibitors metabolism genetics Tumor Suppressor Proteins / genetics metabolism Signal Transduction / drug effects Checkpoint Kinase 1 / antagonists & inhibitors metabolism genetics Mice Checkpoint Kinase 2 / metabolism genetics antagonists & inhibitors Female RNA Interference DNA-Activated Protein Kinase
来 源:
DOI:10.1016/j.canlet.2024.216993
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