Abstract：
Aging leads to an accumulation of cellular mutations and damage, increasing the risk of senescence, apoptosis, and malignant transformation. Cellular senescence, which is pivotal in aging, acts as both a guard against cellular transformation and as a check against cancer progression. It is marked by stable cell cycle arrest, widespread macromolecular changes, a pro-inflammatory profile, and altered gene expression. However, it remains to be determined whether these differing subsets of senescent cells result from unique intrinsic programs or are influenced by their environmental contexts. Multiple transcription regulators and chromatin modifiers contribute to these alterations. Special AT-rich sequence-binding protein 1 (SATB1) stands out as a crucial regulator in this process, orchestrating gene expression by structuring chromatin into loop domains and anchoring DNA elements. This review provides an overview of cellular senescence and delves into the role of SATB1 in senescence-related diseases. It highlights SATB1\'s potential in developing antiaging and anticancer strategies, potentially contributing to improved quality of life and addressing aging-related diseases.
摘要：
衰老导致细胞突变和损伤的积累，增加衰老的风险，凋亡，恶性转化。细胞衰老,这是衰老的关键，既可以预防细胞转化，又可以预防癌症进展。它的特点是稳定的细胞周期停滞，广泛的大分子变化，促炎的轮廓，和改变基因表达。然而,这些不同的衰老细胞亚群是由独特的内在程序产生的还是受其环境背景的影响仍有待确定。多种转录调节因子和染色质修饰因子有助于这些改变。特殊的富含AT的序列结合蛋白1（SATB1）在这一过程中作为关键的调节因子脱颖而出。通过将染色质结构化为环域和锚定DNA元件来协调基因表达。本文对细胞衰老进行了综述，并探讨了SATB1在衰老相关疾病中的作用。它强调了SATB1在开发抗衰老和抗癌策略方面的潜力，可能有助于改善生活质量和解决衰老相关疾病。
