PDF(Pubmed)
Abstract：
UNASSIGNED: The Bellary district in Karnataka, rich in mineral resources, is a major mining industry, but prolonged exposure to mining can lead to health hazards. The study aims to assess the genotoxic impact of mining pollutants on mine workers using the micro-nucleus (MN) assay.
UNASSIGNED: Cross-sectional study.
UNASSIGNED: A total of 250 individuals (198 males and 52 females) working in mining areas were examined, and their oral findings were recorded in a proforma. For the micro-nucleus assay, buccal smears from 30 individuals working in mining areas with habits, 30 individuals working in mining areas without habits, and 30 individuals residing in non-mining areas (control group) were selected. Smears were stained with Giemsa stain to identity and quantify the MNs.
UNASSIGNED: The frequency of oral mucosal problems among 250 persons working in mining regions was 170 (68.0%) with no oral mucosal conditions, 79 (32.6%) with oral mucosal conditions, 25 (10%) with leukoplakia, 1 (0.4%) with lichen planus, and 8 (3.2%) with ulcerations. Acute necrotising gingivitis was reported in one person (0.4%), candidiasis in two (0.8%), abscess in two (0.8%), OSMF in 39 (15.6%), and oral cancer in two (0.8%). The mean MN count was 2.40 + 1.57 in mine employees with habits, 2.18 + 1.25 in mine workers without habits, and 1.40 + 0.55 in normal healthy controls.
UNASSIGNED: Reduced occupational health risks brought on by exposure to mining contaminants require protective measures. After being exposed to mining pollutants, exfoliated buccal mucosal cells can be examined for genotoxicity.
UNASSIGNED: Cross-sectional study.
UNASSIGNED: A total of 250 individuals (198 males and 52 females) working in mining areas were examined, and their oral findings were recorded in a proforma. For the micro-nucleus assay, buccal smears from 30 individuals working in mining areas with habits, 30 individuals working in mining areas without habits, and 30 individuals residing in non-mining areas (control group) were selected. Smears were stained with Giemsa stain to identity and quantify the MNs.
UNASSIGNED: The frequency of oral mucosal problems among 250 persons working in mining regions was 170 (68.0%) with no oral mucosal conditions, 79 (32.6%) with oral mucosal conditions, 25 (10%) with leukoplakia, 1 (0.4%) with lichen planus, and 8 (3.2%) with ulcerations. Acute necrotising gingivitis was reported in one person (0.4%), candidiasis in two (0.8%), abscess in two (0.8%), OSMF in 39 (15.6%), and oral cancer in two (0.8%). The mean MN count was 2.40 + 1.57 in mine employees with habits, 2.18 + 1.25 in mine workers without habits, and 1.40 + 0.55 in normal healthy controls.
UNASSIGNED: Reduced occupational health risks brought on by exposure to mining contaminants require protective measures. After being exposed to mining pollutants, exfoliated buccal mucosal cells can be examined for genotoxicity.
摘要：
■卡纳塔克邦的贝拉里区，矿产资源丰富,是一个主要的采矿业，但是长时间接触采矿会导致健康危害。该研究旨在使用微核（MN）测定法评估采矿污染物对矿山工人的遗传毒性影响。
■横断面研究。
■共检查了在矿区工作的250个人（198名男性和52名女性），他们的口头发现以形式记录。对于微核测定，来自30名在矿区工作的有习惯的人的口腔涂片，30个人在矿区工作没有习惯，选择居住在非矿区的30人（对照组）。涂片用Giemsa染色剂染色以鉴定和定量MN。
■在矿区工作的250个人中，没有口腔黏膜疾病的口腔黏膜问题的频率为170（68.0％），79（32.6％）患有口腔粘膜疾病，25（10％）患有白斑，1例（0.4%）扁平苔藓，溃疡8例（3.2%）。急性坏死性牙龈炎报告1人（0.4%），念珠菌病两例(0.8%)，两个脓肿（0.8％），OSMF在39（15.6%），和口腔癌两个（0.8％）。有习惯的矿山员工的平均MN计数为2.40+1.57，2.18+1.25在没有习惯的矿井工人中，正常健康对照组为1.40+0.55。
■减少接触采矿污染物带来的职业健康风险需要采取保护措施。暴露于采矿污染物后，可以检查脱落的口腔粘膜细胞的遗传毒性。
■横断面研究。
■共检查了在矿区工作的250个人（198名男性和52名女性），他们的口头发现以形式记录。对于微核测定，来自30名在矿区工作的有习惯的人的口腔涂片，30个人在矿区工作没有习惯，选择居住在非矿区的30人（对照组）。涂片用Giemsa染色剂染色以鉴定和定量MN。
■在矿区工作的250个人中，没有口腔黏膜疾病的口腔黏膜问题的频率为170（68.0％），79（32.6％）患有口腔粘膜疾病，25（10％）患有白斑，1例（0.4%）扁平苔藓，溃疡8例（3.2%）。急性坏死性牙龈炎报告1人（0.4%），念珠菌病两例(0.8%)，两个脓肿（0.8％），OSMF在39（15.6%），和口腔癌两个（0.8％）。有习惯的矿山员工的平均MN计数为2.40+1.57，2.18+1.25在没有习惯的矿井工人中，正常健康对照组为1.40+0.55。
■减少接触采矿污染物带来的职业健康风险需要采取保护措施。暴露于采矿污染物后，可以检查脱落的口腔粘膜细胞的遗传毒性。
