METHODS: A retrospective observational study was conducted on the cases received in the Department of Pathology over the period of January 2021 to December 2021. The study analyzed cases of OSCC, focusing on various factors such as age, gender, habits, tumor site, tumor size, differentiation, tumor-stroma ratio, tumor-infiltrating lymphocytes, tumor budding, worst pattern of invasion, depth of invasion, perineural invasion, lymphovascular invasion, underlying bone and overlying skin involvement, regional lymph node metastasis, and overall two-year survival.
RESULTS: The mean age of the patients was 47.80 ± 12.48 years, and the male-to-female ratio was 15.6:1. Buccal mucosa was the most frequently affected site followed by the tongue. Fifty-six percent of cases reported with a history of tobacco abuse. Thirty-six percent of the patients had regional lymph node metastasis and exhibited a strong association with younger age, substance abuse, higher tumor size, tongue as a site, moderate-to-poor tumor differentiation, low tumor-infiltrating lymphocytes, and higher perineural and lymphovascular invasion. Moreover, at the end of the two-year survival analysis, 34% of patients succumbed to the disease. Overall survival was observed to be significantly better with <2 cm maximum tumor size, well-differentiated tumor morphology, higher tumor-infiltrating lymphocytes, and no nodal metastasis.
CONCLUSIONS: The study highlights the intricate correlations of various histopathological factors in OSCC, shedding light on their potential implications for prognosis.
方法:在2021年1月至2021年12月期间,对病理科接收的病例进行了回顾性观察性研究。该研究分析了OSCC的病例,关注各种因素,如年龄,性别,习惯,肿瘤部位,肿瘤大小,分化,肿瘤基质比,肿瘤浸润淋巴细胞,肿瘤出芽,最糟糕的入侵模式,入侵深度,神经周浸润,淋巴管浸润,下面的骨和上面的皮肤受累,区域淋巴结转移,和2年总生存率。
结果:患者的平均年龄为47.80±12.48岁,男女比例为15.6:1。颊粘膜是最常见的受影响的部位,其次是舌头。56%的病例报告有烟草滥用史。36%的患者有区域淋巴结转移,并表现出与年龄较小的强烈关联。药物滥用,肿瘤大小较大,舌头作为一个部位,中度至重度肿瘤分化,低肿瘤浸润淋巴细胞,和更高的神经周和淋巴血管侵犯。此外,在两年生存分析结束时,34%的患者死于该疾病。观察到肿瘤最大尺寸<2cm时,总生存期明显更好。分化良好的肿瘤形态学,较高的肿瘤浸润淋巴细胞,没有淋巴结转移.
结论:该研究强调了OSCC中各种组织病理学因素的复杂相关性,阐明它们对预后的潜在影响。