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Abstract：
Our understanding and management of reproductive health and related disorders such as infertility, menstrual irregularities, and pituitary disorders depend on understanding the intricate sex-specific mechanisms governing prolactin secretion. Using ex vivo experiments in acute slices, in parallel with in vivo calcium imaging (GRIN lens technology), we found that dopamine neurons inhibiting PRL secretion (TIDA), organize as functional networks both in and ex vivo. We defined an index of efficiency of networking (Ieff) using the duration of calcium events and the ability to form plastic economic networks. It determined TIDA neurons\' ability to inhibit PRL secretion in vivo. Ieff variations in both sexes demonstrated TIDA neurons\' adaptability to physiological changes. A variation in the number of active neurons contributing to the network explains the sexual dimorphism in basal [PRL]blood secretion patterns. These sex-specific differences in neuronal activity and network organization contribute to the understanding of hormone regulation.
摘要：
我们对生殖健康和不育等相关疾病的理解和管理，月经不调,和垂体疾病取决于了解控制催乳素分泌的复杂的性别特异性机制。在急性切片中使用离体实验，与体内钙成像（GRIN透镜技术）并行，我们发现多巴胺神经元抑制PRL分泌（TIDA），在体内和体外组织为功能网络。我们使用钙事件的持续时间和形成塑料经济网络的能力来定义网络效率指数（Ieff）。它确定了TIDA神经元在体内抑制PRL分泌的能力。两性的差异证明了TIDA神经元对生理变化的适应性。有助于网络的活跃神经元数量的变化解释了基础[PRL]血液分泌模式中的性二态性。神经元活动和网络组织的这些性别特异性差异有助于理解激素调节。
