PDF(Pubmed)
Abstract：
Ocular toxoplasmosis (OT) is an intraocular infection caused by the parasite Toxoplasma gondii. OT is manifested as retinal choroiditis and is the most common infectious cause of posterior uveitis. Invasion of the retina by T. gondii leads to disruption of the blood-ocular barrier and promotes the migration of immune cells to the ocular tissues. Cytokines such as IFN-γ and IL-1β are effective for controlling parasite growth, but excessive inflammatory responses can cause damage to the host. In this review, we will discuss in detail the latest advances in the immunopathology and treatment of OT.
摘要：
眼弓形虫病（OT）是由弓形虫寄生虫引起的眼内感染。OT表现为视网膜脉络膜炎，是后葡萄膜炎最常见的感染性原因。弓形虫对视网膜的侵入导致血眼屏障的破坏并促进免疫细胞向眼部组织的迁移。细胞因子如IFN-γ和IL-1β可有效控制寄生虫的生长，但是过度的炎症反应会对宿主造成损害。在这次审查中,我们将详细讨论OT的免疫病理学和治疗的最新进展。
