关键词: cerebral malaria murine model pathogenesis response to treatment

Mesh : Malaria, Cerebral / physiopathology parasitology Animals Mice Disease Models, Animal Brain Edema / parasitology Humans

来  源:   DOI:10.1016/j.pt.2024.05.008

Abstract:
A complex series of studies by Oelschlegel et al. in a murine model of cerebral malaria establishes a temporal sequence of events linking decreased venous efflux to impaired perfusion, edema, and neuroinflammation. The relevance to human cerebral malaria is discussed, including the heterogeneity recognized in recent investigations of cerebrovascular hemodynamics.
摘要:
Oelschlegel等人的一系列复杂的研究。在脑型疟疾的鼠模型中,建立了将静脉外排减少与灌注受损联系起来的事件的时间序列,水肿,和神经炎症。讨论了与人脑型疟疾的相关性,包括在最近的脑血管血流动力学研究中认识到的异质性。
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