Abstract：
Mitochondria play a crucial role in cellular metabolism and bioenergetics, orchestrating various cellular processes, including energy production, metabolism, adaptation to stress, and redox balance. Besides, mitochondria regulate cellular metabolic homeostasis through coordination with multiple signaling pathways. Importantly, the p38 mitogen-activated protein kinase (MAPK) signaling pathway is a key player in the intricate communication with mitochondria, influencing various functions. This review explores the multifaced interaction between the mitochondria and p38 MAPK signaling and the consequent impact on metabolic alterations. Overall, the p38 MAPK pathway governs the activities of key mitochondrial proteins, which are involved in mitochondrial biogenesis, oxidative phosphorylation, thermogenesis, and iron homeostasis. Additionally, p38 MAPK contributes to the regulation of mitochondrial responses to oxidative stress and apoptosis induced by cancer therapies or natural substances by coordinating with other pathways responsible for energy homeostasis. Therefore, dysregulation of these interconnected pathways can lead to various pathologies characterized by aberrant metabolism. Consequently, gaining a deeper understanding of the interaction between mitochondria and the p38 MAPK pathway and their implications presents exciting forecasts for novel therapeutic interventions in cancer and other disorders characterized by metabolic dysregulation.
摘要：
线粒体在细胞代谢和生物能学中发挥着至关重要的作用,协调各种细胞过程，包括能源生产，新陈代谢，适应压力，和氧化还原平衡。此外,线粒体通过与多个信号通路协调调节细胞代谢稳态。重要的是,p38丝裂原活化蛋白激酶（MAPK）信号通路是与线粒体复杂通讯的关键，影响各种功能。这篇综述探讨了线粒体和p38MAPK信号之间的多面性相互作用及其对代谢改变的影响。总的来说,p38MAPK通路控制着关键线粒体蛋白的活性，参与线粒体生物发生，氧化磷酸化，产热,和铁稳态。此外,p38MAPK通过与负责能量稳态的其他途径协调，有助于调节线粒体对癌症疗法或天然物质诱导的氧化应激和凋亡的反应。因此,这些相互关联的途径的失调可导致以异常代谢为特征的各种病理。因此,对线粒体与p38MAPK通路之间的相互作用及其意义有了更深入的了解,为癌症和其他以代谢失调为特征的疾病的新型治疗干预提供了令人兴奋的预测.
