Abstract：
pathological pain and Attention-deficit/hyperactivity disorder (ADHD) are two complex multifactorial syndromes. The comorbidity of ADHD and altered pain perception is well documented in children, adolescents, and adults. According to pathophysiological investigations, the dopaminergic system\'s dysfunction provides a common basis for ADHD and comorbid pain. Growing evidence suggests that oxidative stress may be crucial in both pathologies. Recent studies revealed that a small peptide encompassing the redox-active site of selenoprotein T (PSELT), protects dopaminergic neurons and fibers as well as lesioned nerves in animal models. The current study aims to examine the effects of PSELT treatment on ADHD-like symptoms and pain sensitivity, as well as the role of catecholaminergic systems in these effects. Our results demonstrated that intranasal administration of PSELT reduced the hyperactivity in the open field, decreased the impulsivity displayed by 6-OHDA-lesioned male mice in the 5-choice serial reaction time task test and improved attentional performance. In addition, PSELT treatment significantly increased the nociception threshold in both normal and inflammatory conditions. Furthermore, anti-hyperalgesic activity was antagonized with sulpiride pre-treatment, but not by phentolamine, or propranolol pre-treatments. The present study suggests that PSELT reduces the severity of ADHD symptoms in mice and possesses potent antinociceptive effects which could be related to the involvement of D2/D3 dopaminergic receptors.
摘要：
病理性疼痛和注意力缺陷多动障碍（ADHD）是两种复杂的多因素综合征。儿童多动症和疼痛感知改变的合并症有很好的记录，青少年,和成年人。根据病理生理调查，多巴胺能系统功能障碍为多动症和共病疼痛提供了共同基础。越来越多的证据表明，氧化应激在两种病理中都是至关重要的。最近的研究表明，包含硒蛋白T（PSELT）的氧化还原活性位点的小肽，在动物模型中保护多巴胺能神经元和纤维以及受损神经。本研究旨在研究PSELT治疗对ADHD样症状和疼痛敏感性的影响，以及儿茶酚胺能系统在这些作用中的作用。我们的结果表明，鼻内给药PSELT减少了开放视野中的过度活跃，在5选择系列反应时间任务测试中，降低了6-OHDA损伤的雄性小鼠显示的冲动性，并改善了注意力表现。此外,PSELT治疗在正常和炎症条件下均显著增加了伤害感受阈值。此外，抗痛觉过敏活性与舒必利预处理拮抗，但不是酚妥拉明，或者普萘洛尔预处理.本研究表明，PSELT可降低小鼠ADHD症状的严重程度，并具有有效的镇痛作用，这可能与D2/D3多巴胺能受体的参与有关。
